P7888
DL-Propargylglycine
cystathionine γ-lyase inhibitor
Synonym(s):
2-Amino-4-pentynoic acid, PAG
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About This Item
Empirical Formula (Hill Notation):
C5H7NO2
CAS Number:
Molecular Weight:
113.11
MDL number:
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26
Recommended Products
assay
≥98% (TLC)
form
powder
color
white
application(s)
cell analysis
storage temp.
−20°C
SMILES string
NC(CC#C)C(O)=O
InChI
1S/C5H7NO2/c1-2-3-4(6)5(7)8/h1,4H,3,6H2,(H,7,8)
InChI key
DGYHPLMPMRKMPD-UHFFFAOYSA-N
Related Categories
Application
- Metabolic Labeling Strategy Boosted Antibacterial Efficiency for Photothermal and Photodynamic Synergistic Bacteria-Infected Wound Therapy.: This study demonstrates the enhanced antibacterial efficiency of a metabolic labeling strategy using ᴅʟ-Propargylglycine in photothermal and photodynamic therapy for treating bacteria-infected wounds (Li et al., 2022).
- Metabolic Labeling of Peptidoglycan with NIR-II Dye Enables In Vivo Imaging of Gut Microbiota.: This research utilizes ᴅʟ-Propargylglycine for metabolic labeling, allowing near-infrared II imaging of gut microbiota in vivo, providing new insights into microbiome studies (Wang et al., 2020).
- Hydrogen sulfide upregulated mRNA expressions of sodium bicarbonate cotransporter1, trefoil factor1 and trefoil factor2 in gastric mucosa in rats.: Investigates the role of ᴅʟ-Propargylglycine, in upregulating specific mRNA expressions in gastric mucosa, with implications for gastrointestinal research (Cheraghi et al., 2016).
Biochem/physiol Actions
DL-Propargylglycine (PAG) is an irreversible inhibitor of the enzyme cystathionine γ-lyase (GCL), a key enzyme involved in glutathione synthesis and the metabolic transsulfuration pathway which regulates homocysteine concentration and mediates cysteine synthesis. Treatment of animal disease models with PAG was shown to alleviate symptoms of diseases that impair the formation or action of hydrogen sulfide (H2S).
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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