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Key Documents

P3807

Sigma-Aldrich

pGlu-Asp-Pro-Phe-Leu-Arg-Phe-NH2

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C44H61N11O10
CAS Number:
Molecular Weight:
904.02
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:

assay

≥97% (HPLC)

storage temp.

−20°C

SMILES string

CC(C)CC(NC(=O)C(Cc1ccccc1)NC(=O)C2CCCN2C(=O)C(CC(O)=O)NC(=O)C3CCC(=O)N3)C(=O)NC(CCCNC(N)=N)C(=O)NC(Cc4ccccc4)C(N)=O

Other Notes

FMRF-like peptide originally isolated from snail (Helix aspersa)

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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K G Krajniak et al.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 94(2), 485-492 (1989-01-01)
1. The molluscan neuropeptides FMRFamide, pQDPFLRFamide, and SCPB were tested on the isolated crop and penis of the terrestraial slug, Limax maximus. FMRFamide and pQDPFLRFamide stimulated the penis and inhibited contractions of the crop. In contrast, SCPB either stimulated or
R F Geraghty et al.
Peptides, 15(5), 835-841 (1994-01-01)
To investigate the role of the N-terminal region of the heptapeptide FMRFamide-like peptide, pQDPFLRFamide, three analogues were synthesized. The analogues [pQNPFLRFamide, pQDAibFLRFamide (Aib = aminoisobutyric acid) and pQDGFLRFamide] contained modifications at amino acid residues 2 and 3, which we believed
W Lesser et al.
Peptides, 18(6), 909-911 (1997-01-01)
The endogenous neuropeptides FMRFamide and FLRFamide (tetrapeptides) reversibly reduced a voltage-activated calcium current in the C1 neuron of Helix aspersa by an average of 20%. Two structurally related heptapeptides, pQDPFLRFamide and pQDPFLRIamide, both derived from another precursor protein in this
Price, D.A., et al.
The Biological Bulletin, 169, 256-256 (1985)
S W Falconer et al.
Experimental physiology, 78(6), 757-766 (1993-11-01)
The C3 neurone, which acts as a motoneurone for the tentacle retractor muscle in Helix aspersa, contains both Phe-Met-Arg-Phe-NH2 (FMRFamide) and acetylcholine (ACh). Each of these transmitter substances evokes contraction of the isolated muscle. FMRFamide induces a delayed rise in

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