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P3807

Sigma-Aldrich

pGlu-Asp-Pro-Phe-Leu-Arg-Phe-NH2

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C44H61N11O10
CAS Number:
Molecular Weight:
904.02
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:

assay

≥97% (HPLC)

storage temp.

−20°C

SMILES string

CC(C)CC(NC(=O)C(Cc1ccccc1)NC(=O)C2CCCN2C(=O)C(CC(O)=O)NC(=O)C3CCC(=O)N3)C(=O)NC(CCCNC(N)=N)C(=O)NC(Cc4ccccc4)C(N)=O

Other Notes

FMRF-like peptide originally isolated from snail (Helix aspersa)

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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H R Khan et al.
The Journal of comparative neurology, 393(1), 25-33 (1998-03-31)
Serotonergic neurons were studied by specific histological methods, and neurons containing Phe-Met-Arg-Phe-NH2 (FMRFamide)-related heptapeptides were identified with an antiserum specific for these substances in the central nervous system of the freshwater snail Helisoma duryi. Serotonergic neurons and their axons are
H K Lehman et al.
The Journal of experimental biology, 131, 55-68 (1987-09-01)
Phe-Met-Arg-Phe-NH2 (FMRFamide) and pyroGlu-Asp-Pro-Phe-Leu-Arg-Phe-NH2 (pQDPFLRFamide) occur in the ganglia and tissues of the snail, Helix aspersa. This report describes the effects of these two neuropeptides on five visceral organs or somatic muscles isolated from the snail (Table 1). The epiphallus
M Macdonald et al.
Molecular and cellular neurosciences, 5(1), 23-34 (1994-02-01)
The FMRFamide-related peptides (FaRPs) of Helix fall into two groups with often different pharmacological effects: the tetrapeptides FMRFamide and FLRFamide (tetraFaRPs) and the heptapeptides, which have the general structure XDP(F or Y)LRFamide (heptaFaRPs). Previously, we have shown that each group
Price, D.A., et al.
The Biological Bulletin, 169, 256-256 (1985)
V I Deĭgin et al.
Zhurnal evoliutsionnoi biokhimii i fiziologii, 24(1), 106-108 (1988-01-01)
New FMRF-amide like peptide, pGlu-Asp-Pro-Phe-Leu-Arg-Phe-NH2, originally isolated from the ganglia of Helix aspersa, was synthetized. Intravenous injections of this peptide (40-300 micrograms/kg) produce rapid dose dependent increase in the blood pressure and heart rate of anaesthetised rats. Since alpha-adrenoreceptor blockade

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