Skip to Content
MilliporeSigma
All Photos(1)

Documents

P3761

Sigma-Aldrich

Pentobarbital sodium salt

Synonym(s):

5-Ethyl-5-(1-methylbutyl)-2,4,6-trioxohexahydropyrimidine, Nembutal

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C11H17N2NaO3
CAS Number:
57-33-0
Molecular Weight:
248.25
EC Number:
200-323-9
MDL number:
MFCD00070198
UNSPSC Code:
41116107
PubChem Substance ID:
24898448

form

powder

drug control

USDEA Schedule II; Home Office Schedule 3; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada

solubility

H2O: soluble
alcohol: soluble

SMILES string

[Na].CCCC(C)C1(CC)C(=O)NC(=O)NC1=O

InChI

1S/C11H18N2O3.Na.H/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15;;/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16);;

InChI key

PGOYUXGHADTNIB-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Application

Pentobarbital sodium salt has been used as an anesthetic in rats and mice prior to various in vitro studies.

Biochem/physiol Actions

Pentobarbital (PB) is a barbiturate and a ligand of the γ-aminobutyric acid subtype A (GABAA) receptor. It is a sedative anesthetic majorly used in rodent euthanasia. Pentobarbital possesses hypnotic functionality and muscle relaxing properties. It enhances GABAergic activity. Intraperitoneal injection of PB may result in loss of righting reflex (LORR) and heartbeat cessation.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Repr. 2 - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 2

1 of 2

Phenobarbital solution 1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

P-008

Phenobarbital solution

vibrant-m

BP736

Ketamine hydrochloride

Issei Takeuchi et al.
Colloids and surfaces. B, Biointerfaces, 155, 35-40 (2017-04-10)
Postmenopausal osteoporosis among older women, which occurs by an ovarian hormone deficiency, is one of the major public health problems. 17 β-estradiol (E2) is used to prevent and treat this disease as a drug of hormone replacement therapy. In oral
Martina Ceckova et al.
Antimicrobial agents and chemotherapy, 60(9), 5563-5572 (2016-07-13)
Lamivudine is one of the antiretroviral drugs of choice for the prevention of mother-to-child transmission (MTCT) in HIV-positive women. In this study, we investigated the relevance of drug efflux transporters P-glycoprotein (P-gp) (MDR1 [ABCB1]), BCRP (ABCG2), MRP2 (ABCC2), and MATE1
Minfeng Chen et al.
The Journal of clinical investigation, 127(10), 3689-3701 (2017-08-29)
Blood vessels in the tumor periphery have high pericyte coverage and are resistant to vascular disrupting agents (VDAs). VDA treatment resistance leads to a viable peripheral tumor rim that contributes to treatment failure and disease recurrence. Here, we provide evidence
Issei Takeuchi et al.
Bio-medical materials and engineering, 27(5), 475-483 (2016-11-26)
Estradiol is one of the therapeutic agents for osteoporosis. We have reported transdermal permeability of estradiol-loaded nanoparticles, and permeability effect of estradiol was enhanced by using nanoparticle system and iontophoresis [Colloids and Surfaces B: Biointerfaces97 (2012), 84-89]. This study was
Yi Wang et al.
Asian journal of andrology, 21(5), 452-459 (2019-03-19)
This study aimed to investigate the functional and morphological changes in the corpus cavernosum after cavernous nerve (CN) injury or neurectomy and then reveal whether treatment with the angiotensin II Type 1 receptor antagonist losartan would improve erectile function as
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service