P3513
Poly-L-lysine, succinylated
mol wt >50,000
Synonym(s):
Modified Lysine Copolymer
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About This Item
Pricing and availability is not currently available.
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form
powder or solid
Quality Level
mol wt
>50,000
color
white to faint yellow
application(s)
cell analysis
storage temp.
−20°C
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Application
Succinylated poly-L-lysine has been used to bind (Gly)3-Arg-bradykinin to study its hydrolysis by brain endopeptidases and pancreatic proteinases.[1]
Biochem/physiol Actions
Poly-L-lysine is a cationic polymer. It is mainly used for immobilizing cells to glass substrates or negatively charged substrates.[2][3]
An intermediate for coupling proteins to poly-L-lysine.
Analysis Note
Molecular weight based on precursor poly-L-lysine viscosity. Also assayed by MALLS.
Other Notes
For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Susceptibility of a Peptide Derived from Bradykinin to Hydrolysis by Brain Endo-oligopeptidases and Pancreatic Proteinases*
Antonio C. M. Camargo
The Journal of Biological Chemistry, 254(12), 5304-5307 (1979)
M R Hamblin et al.
British journal of cancer, 89(5), 937-943 (2003-08-28)
Conjugates between photosensitisers (PS) and charged polymeric carriers are under investigation for photodynamic therapy of cancer and may allow targeting to certain cell types or compartments in tumours. Covalent attachment of polyethylene glycol to macromolecules (pegylation) may alter their pharmacokinetics
Sofia Helena Linnea Frost et al.
Cancer biotherapy & radiopharmaceuticals, 26(6), 727-736 (2011-11-18)
Avidin-coupled monoclonal antibody MX35 (avidin-MX35) and astatine-211-labeled, biotinylated, succinylated poly-l-lysine ((211)At-B-PL(suc)) were administered in mice to assess potential efficacy as an intraperitoneal (i.p.) therapy for microscopic tumors. We aimed to establish a timeline for pretargeted radioimmunotherapy using these substances, and
Effects of poly(L-lysine) substrates on attached Escherichia coli bacteria.
Colville K
Langmuir, 26(4), 2639-2644 (2010)
Topographical Pattern Dynamics in Passive Adhesion of Cell Membranes
Alina Hategan
Biophysical Journal, 87(5), 3547?3560-3547?3560 (2004)
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