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N1134

Sigma-Aldrich

Se-(p-Nitrobenzyl)-6-selenoinosine

≥95%

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About This Item

Linear Formula:
C17H17SeN5O6
CAS Number:
40144-12-5
Molecular Weight:
466.31
MDL number:
MFCD00056966
UNSPSC Code:
41106305
PubChem Substance ID:
24897462

assay

≥95%

form

solid

storage temp.

−20°C

SMILES string

OCC1OC(C(O)C1O)n2cnc3c([Se]Cc4ccc(cc4)N(=O)=O)ncnc23

InChI

1S/C17H17N5O6Se/c23-5-11-13(24)14(25)17(28-11)21-8-20-12-15(21)18-7-19-16(12)29-6-9-1-3-10(4-2-9)22(26)27/h1-4,7-8,11,13-14,17,23-25H,5-6H2

InChI key

XCNANXPIYMOXKW-UHFFFAOYSA-N

Biochem/physiol Actions

Se-(p-nitrobenzyl)-6-selenoinosine is a selenium containing inosine derivative that may have activities similar to S-(p-nitrobenzyl)-6-thioinosine (NBTI), an inhibitor of adenosine equilibrative transporters.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificates of Analysis (COA)

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M A Timóteo et al.
Neurochemistry international, 52(4-5), 834-845 (2007-11-21)
The influence of nerve stimulation pattern on transmitter release inhibition by L-citrulline, the co-product of NO biosynthesis by nitric oxide synthase (NOS), was studied in the rat phrenic nerve-hemidiaphragm. We also investigated the putative interactions between NOS pathway and the
Sílvia V Conde et al.
Journal of neurochemistry, 89(5), 1148-1156 (2004-05-19)
The effect of hypoxia on the release of adenosine was studied in vitro in the rat whole carotid body (CB) and compared with the effect of hypoxia (2%, 5% and 10% O(2)) on adenosine concentrations in superior cervical ganglia (SCG)
Alexandre dos Santos-Rodrigues et al.
Biochemical and biophysical research communications, 414(1), 175-180 (2011-09-29)
Adenosine is an important modulator of neuronal survival and differentiation in the CNS. Our previous work showed that nucleoside transporters (NTs) are present in cultures of chick retinal cells, but little is known about the mechanisms regulating adenosine transport in
Laura Oliveira et al.
Neuroscience letters, 459(3), 127-131 (2009-05-12)
At the rat motor nerve terminals, activation of muscarinic M(1) receptors negatively modulates the activity of inhibitory muscarinic M(2) receptors. The present work was designed to investigate if the negative crosstalk between muscarinic M(1) and M(2) autoreceptors involved endogenous adenosine

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