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M6524

Sigma-Aldrich

Methoxamine hydrochloride

Synonym(s):

α-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C11H17NO3 · HCl
CAS Number:
Molecular Weight:
247.72
EC Number:
MDL number:
UNSPSC Code:
12352116
PubChem Substance ID:
NACRES:
NA.77

storage temp.

2-8°C

SMILES string

Cl[H].COc1ccc(OC)c(c1)C(O)C(C)N

InChI

1S/C11H17NO3.ClH/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3;/h4-7,11,13H,12H2,1-3H3;1H

InChI key

YGRFXPCHZBRUKP-UHFFFAOYSA-N

Gene Information

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Related Categories

Biochem/physiol Actions

α1-adrenoceptor agonist.

Features and Benefits

This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificates of Analysis (COA)

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Sven Francque et al.
Laboratory investigation; a journal of technical methods and pathology, 92(10), 1428-1439 (2012-08-15)
Non-alcoholic fatty liver disease can progress to steatohepatitis and fibrosis, and is also associated with impaired liver regeneration. The pathophysiology remains elusive. We recently showed that severe steatosis is associated with an increase in portal pressure, suggesting liver flow impairment.
Hideko Inaba et al.
Circulation journal : official journal of the Japanese Circulation Society, 75(1), 89-93 (2010-12-09)
Anesthesia sometimes suppresses ventricular tachyarrhythmias (VT) resistant to conventional pharmacological treatment. To know (1) whether deep anesthesia inhibits abnormal repolarization-related VT and (2) if α2-adrenoreceptor (AR) agonistic action is associated with the antiarrhythmic effect of anesthetics, the incidence of VT
Manuel Hernández-Guerra et al.
Hepatology (Baltimore, Md.), 57(4), 1564-1574 (2012-11-24)
Chronic intermittent hypoxia (CIH) occurs with obstructive sleep apnea syndrome (OSAS) and provokes systemic endothelial dysfunction, which is associated with oxidative stress and low nitric oxide (NO) bioavailability. Cirrhotic livers exhibit intrahepatic endothelial dysfunction, which is characterized by an impaired
Lindsay D MacKenzie et al.
The journal of sexual medicine, 8(9), 2461-2471 (2011-06-29)
Mean arterial pressure (MAP) and specific regulation of penile blood flow are the primary determinants of an erection. While this concept is well recognized, the differential relationship between systemically acting vasoactive factors on arterial pressure and erectile responses is not
ShiYong Huang et al.
Neuron, 73(3), 497-510 (2012-02-14)
Neuromodulatory input, acting on G protein-coupled receptors, is essential for the induction of experience-dependent cortical plasticity. Here we report that G-coupled receptors in layer II/III of visual cortex control the polarity of synaptic plasticity through a pull-push regulation of LTP

Articles

Review alpha 1 adrenoceptors as well as their agonists, antagonists, and tissue expression patterns. We suggest several modulators and alternatives for working with a-1 adrenoreceptors.

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