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M4656

Sigma-Aldrich

(±)-p-Methoxyamphetamine hydrochloride

Synonym(s):

PMA hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C10H15NO · HCl
CAS Number:
52740-56-4
Molecular Weight:
201.69
EC Number:
200-659-6
MDL number:
MFCD00051431
UNSPSC Code:
12352200

drug control

Home Office Schedule 1; kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada

storage temp.

2-8°C

SMILES string

Cl.COc1ccc(CC(C)N)cc1

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Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

51.8 °F - closed cup

flash_point_c

11 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Paul D Callaghan et al.
Journal of neurochemistry, 100(3), 617-627 (2006-12-22)
p-Methoxyamphetamine (PMA) has been implicated in fatalities as a result of 'ecstasy' (MDMA) overdose worldwide. Like MDMA, acute effects are associated with marked changes in serotonergic neurotransmission, but the long-term effects of PMA are poorly understood. The aim of this
M M W Straiko et al.
Neuroscience, 144(1), 223-231 (2006-11-07)
The present study quantified the cleaved form of the microtubule-associated protein tau (cleaved MAP-tau, C-tau), a previously demonstrated marker of CNS toxicity, following the administration of monoamine-depleting regimens of the psychostimulant drugs amphetamine (AMPH), methamphetamine (METH), +/-3,4-methylenedioxymethamphetamine (MDMA), or para-methoxyamphetamine
Amparo Fornés et al.
The Biochemical journal, 412(3), 495-506 (2008-03-18)
The neuronal glycine transporter GLYT2 controls the availability of the neurotransmitter in glycinergic synapses, and the modulation of its function may influence synaptic transmission. The active transporter is located in membrane rafts and reaches the cell surface through intracellular trafficking.
Fatal paramethoxy-amphetamine (PMA) poisoning in the Australian Capital Territory.
Paul G Lamberth et al.
The Medical journal of Australia, 188(7), 426-426 (2008-04-09)
Diego Bustamante et al.
Pharmacology, biochemistry, and behavior, 79(2), 199-212 (2004-10-27)
The analgesic effects of (+)- and (-)-amphetamine (AMPH), (+/-)-p-methoxyamphetamine (MA), (+/-)-N-methyl-p-methoxyamphetamine (MMA) and (+/-)-N-ethyl-p-methoxyamphetamine (EMA) were compared using two different algesimetric tests in rats. In the formalin test, (+)-AMPH elicited significant antinociception at doses of 0.2, 2 and 8 mg/kg
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