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L6670

Sigma-Aldrich

LY266097

≥98% (HPLC), powder

Synonym(s):

1-[(2-Chloro-3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride, LY 266097

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5 MG
$130.15
25 MG
$548.00

$130.15

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5 MG
$130.15
25 MG
$548.00

About This Item

Empirical Formula (Hill Notation):
C21H23ClN2O2 · HCl
CAS Number:
172895-39-5
Molecular Weight:
407.33
MDL number:
MFCD00949080
UNSPSC Code:
12352200
PubChem Substance ID:
329817643
NACRES:
NA.77

$130.15

List price$137.00
Web-Only Promotion

Available to ship onApril 07, 2025Details

Request a Bulk Order

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to tan

solubility

DMSO: ≥20 mg/mL

originator

Eli Lilly

storage temp.

2-8°C

SMILES string

Cl.COc1ccc(CC2NCCc3c2[nH]c4ccc(C)cc34)c(Cl)c1OC

InChI

1S/C21H23ClN2O2.ClH/c1-12-4-6-16-15(10-12)14-8-9-23-17(20(14)24-16)11-13-5-7-18(25-2)21(26-3)19(13)22;/h4-7,10,17,23-24H,8-9,11H2,1-3H3;1H

InChI key

KPXKZZURYAXZQE-UHFFFAOYSA-N

Biochem/physiol Actions

LY266097 is a selective 5HT-2B antagonist with a pKI of 9.7 for the human cloned 5-HT2B receptor and a 100-fold greater selectivity for 5-HT2B than the human 5-HT2C and 5-HT2A.
LY266097 is a selective 5HT-2B antagonist.

Features and Benefits

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
021M4626V

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Céline Devroye et al.
Neuropharmacology, 109, 59-68 (2016-06-05)
Recent studies suggest that the central serotonin2B receptor (5-HT2BR) could be an interesting pharmacological target for treating neuropsychiatric disorders related to dopamine (DA) dysfunction, such as schizophrenia. Thus, the present study was aimed at characterizing the role of 5-HT2BRs in

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