K4389

KR-32568

≥98% (HPLC), solid

• Synonym(s): [5-(2-Methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine
• Empirical Formula (Hill Notation): C₁₃H₁₂FN₃O₂
• CAS Number: 852146-73-7
• Molecular Weight: 261.25
• MDL number: MFCD08705324
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724522
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: solid
• color: white
• solubility: DMSO: ~10 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cc1ccc(F)cc1-c2ccc(o2)C(=O)NC(N)=N
• InChI: 1S/C13H12FN3O2/c1-7-2-3-8(14)6-9(7)10-4-5-11(19-10)12(18)17-13(15)16/h2-6H,1H3,(H4,15,16,17,18)
• InChI key: DTLDHYBZLVASJQ-UHFFFAOYSA-N
• Gene Information: human ... SLC9A1(6548)

Description

Biochem/physiol Actions

Sodium/hydrogen exchanger-1 (NHE-1) inhibitor; IC₅₀ = 0.23 μM; inhibited NHE-1-mediated rabbit platelet swelling; in anesthetized rats, reduced infarct size from 67% (control) to 43% (at 0.1 mg/kg) and 24% (at 1.0 mg/kg); reduced number of ventricular premature beats from 530 to 266 (at 0.1 mg/kg) and 115 (at 1.0 mg/kg); reduced ventricular fibrillation incidence from 17 to 8 (0.1 mg/kg) and 0 (1.0 mg/kg); implications for research and treatment of myocardial ischemic diseases.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter