I134

L-N⁵-(1-Iminoethyl)ornithine hydrochloride

≥95% (HPLC)

• Synonym(s): L-NIO hydrochloride, L-Ornithine ψ-acetamidine hydrochloride
• Empirical Formula (Hill Notation): C₇H₁₅N₃O₂ · xHCl
• CAS Number: 852173-80-9
• Molecular Weight: 173.21 (free base basis)
• MDL number: MFCD00153817
• UNSPSC Code: 12352204
• PubChem Substance ID: 329815348
• NACRES: NA.26

Properties

• assay: ≥95% (HPLC)
• form: powder
• mol wt: calculated mol wt 173.22 g/mol
• storage condition: desiccated; under inert gas
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear (warmed)
• storage temp.: −20°C
• SMILES string: CC(NCCC[C@H](N)C(O)=O)=N.[H]Cl
• InChI: 1S/C7H15N3O2.ClH/c1-5(8)10-4-2-3-6(9)7(11)12;/h6H,2-4,9H2,1H3,(H2,8,10)(H,11,12);1H/t6-;/m0./s1
• InChI key: JIBZSGQTCBWUKL-RGMNGODLSA-N

Description

Application

L-N⁵-(1-Iminoethyl) ornithine hydrochloride has been used to study the effects of the cytotoxic drug paclitaxel and carbachol (a cholinergic agonist) to induce death in breast tumor MCF-7 cells and the role of nitric oxide synthase (NOS) in this effect. It has also been used to study its effects on pulmonary arterial responses to sufentanil in the feline pulmonary vascular bed.

Biochem/physiol Actions

A potent irreversible inhibitor of nitric oxide synthase.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves