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Key Documents

HPA028688

Sigma-Aldrich

Anti-LPO antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

Anti-FLJ23516, Anti-GRAIL, Anti-H2A/m, Anti-H2AFM, Anti-SPO, Anti-lactoperoxidase

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About This Item

MDL number:
UNSPSC Code:
12352203
Human Protein Atlas Number:
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

enhanced validation

orthogonal RNAseq
Learn more about Antibody Enhanced Validation

technique(s)

immunohistochemistry: 1:1000- 1:2500

immunogen sequence

IVGYLNEEGVLDQNRSLLFMQWGQIVDHDLDFAPDTELGSSEYSKAQCDEYCIQGDNCFPIMFPPNDPKAGTQGKCMPFFRAGFVCPTPPYKSLAR

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... LPO(4025)

General description

Lactoperoxidase (LPO), also known as salivary peroxidase (SPO) is an oxidoreductase encoded by the gene mapped to human chromosome 17q22. LPO is secreted from the mammary gland and salivary gland and is present in mature human milk. The encoded protein is a member of mammalian heme peroxidase superfamily.

Immunogen

lactoperoxidase recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

Biochem/physiol Actions

Lactoperoxidase (LPO) catalyzes most of the peroxidase activity in mature milk. It plays a crucial role in protecting the lactating mammary gland and the intestinal tract of the neonate from microbial Infection. LPO is also contributes to the oxidation of various substrates, such as thiocyanate. This enzyme also delivers defense against toxic oxygen by detoxifying hydrogen peroxide in the presence of thiocyanate by converting it into hypothiocyanite, dioxygen and water.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST75753

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Purification and Characterization of Human Salivary Peroxidase
Mansson-Rahemtulla B, et al.
Biochemistry, 27(1), 233-239 (1988)
Molecular cloning and characterization of the chromosomal gene for human lactoperoxidase.
Ueda T, et al.
European Journal of Biochemistry, 243(1?2), 32-41 (1997)
Identification of lactoperoxidase in mature human milk.
Shin K, et al.
The Journal of Nutritional Biochemistry, 11(2), 94-102 (2000)
Salivary peroxidase: an important part of our defense against oxygen toxicity
Carlsson J, et al.
Journal of Oral Pathology & Medicine, 16(8), 412-416 (1987)
Design of anti-thyroid drugs: Binding studies and structure determination of the complex of lactoperoxidase with 2-mercaptoimidazole at 2.30 ? resolution.
Sirohi HV, et al.
Proteins: Structure, Function, and Genetics (2017)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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