H4131
Hemoglobin porcine
lyophilized powder
Synonym(s):
Hb
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About This Item
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biological source
Porcine
form
lyophilized powder
solubility
H2O: soluble 10 mg/mL
storage temp.
2-8°C
Gene Information
pig ... HBB(407066) , HBE1(407067)
General description
Hemoglobin is the major component of red blood cells, and is responsible for their red color. Its normal concentration in erythrocytes is 34%. Hemoglobin is the most important respiratory protein of vertebrates by virtue of its ability to transport oxygen from the lungs to body tissues, and to facilitate the return transport of carbon dioxide.
Application
Hemoglobin from porcine was used to test the role of the L-arginine/nitric oxide pathway in relaxation of isolated human penile cavernous tissue and circumflex veins. It was also used to study the role of nitric oxide in neurogenic vasodilation of porcine cerebral artery.
Biochem/physiol Actions
The Fe2+/Fe3+ balance is a physiological indicator of blood oxygenation. Deoxygenated hemoglobin accessorizes a feedback loop by reducing nitrite to NO, a vasodilator which enhances blood flow to oxygen-deprived tissues.
Oxygen transporter, NO scavenger
Caution
Since native hemoglobin is readily oxidized in air, these preparations may be predominantly methemoglobin.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificates of Analysis (COA)
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F Y Chen et al.
The Journal of pharmacology and experimental therapeutics, 265(1), 339-345 (1993-04-01)
A superfusion bioassay cascade, with porcine pial arteries as donor tissues and rabbit aortic rings as detector tissues, was used to examine the role of nitric oxide (NO) in cerebral nonadrenergic, noncholinergic neurogenic vasodilation. All arteries were mechanically denuded of
H J Kirkeby et al.
Acta physiologica Scandinavica, 149(3), 385-392 (1993-11-01)
In human penile corpus cavernosum strips, pre-contracted by noradrenaline, electrical stimulation of nerves evoked non-adrenergic, non-cholinergic (NANC) relaxant responses which could be inhibited by tetrodotoxin 10(-6) M, NG-nitro-L-arginine (L-NNA) 10(-7)-10(-4) M, and oxyhaemoglobin 10(-5) M, but not by methylene blue
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