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H1406

Sigma-Aldrich

(R)-(+)-8-Hydroxy-DPAT hydrobromide

Synonym(s):

(R)-(+)-2-Dipropylamino-8-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide, (R)-(+)-8-Hydroxy-2-(dipropylamino)tetralin hydrobromide

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About This Item

Empirical Formula (Hill Notation):
C16H25NO · HBr
CAS Number:
78095-19-9
Molecular Weight:
328.29
MDL number:
MFCD00153810
UNSPSC Code:
12352200

SMILES string

Br.CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1

InChI

1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H/t14-;/m1./s1

InChI key

BATPBOZTBNNDLN-PFEQFJNWSA-N

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Biochem/physiol Actions

(R)-(+)-8-Hydroxy-DPAT is a full 5-HT1A serotonin receptor agonist; active enantiomer of (±)-8-hydroxy-DPAT.
5-HT1A serotonin receptor agonist

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GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
127H1005
118H0437
088H0795
059H0600
058H1121

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L J Cornfield et al.
Molecular pharmacology, 39(6), 780-787 (1991-06-01)
Although many different types of compounds have been tested for 5-hydroxytryptamine1A (5-HT1A) binding affinity, much remains to be learned about the structural requirements associated with 5-HT1A agonism, partial agonism, and antagonism. The present study uses the forskolin-stimulated adenylate cyclase (FSC)
B Restrepo et al.
Pharmacology, 90(3-4), 169-176 (2012-09-06)
We investigated the mechanisms involved in the 5-hydroxytriptaminergic inhibitory action on the pressor responses elicited by sympathostimulation in long-term-diabetic pithed rats. Diabetes was induced in rats by alloxan administration. Eight weeks later, the animals were anaesthetized and pithed. The action
Rachel L Dennis et al.
Aggressive behavior, 39(2), 91-98 (2013-02-07)
Prenatal stress can alter the serotonin (5-HT) system in the developing and adult brain and lead to mood and behavioral disorders in children and adults. The chicken provides a unique animal model to study the effects of embryonic stressors on
Nina Nevalainen et al.
PloS one, 8(2), e55706-e55706 (2013-02-08)
L-DOPA-induced dyskinesia is a common side effect developed after chronic treatment with 3,4-dihydroxyphenyl-l-alanine (l-DOPA) in Parkinson's disease. The biological mechanisms behind this side effect are not fully comprehended although involvement of dopaminergic, serotonergic, and glutamatergic systems has been suggested. The
Stéphanie Fournier et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(2), 563-573 (2013-01-11)
Recurrent apneas are important causes of hospitalization and morbidity in newborns. Gestational stress (GS) compromises fetal brain development. Maternal stress and anxiety during gestation are linked to respiratory disorders in newborns; however, the mechanisms remain unknown. Here, we tested the
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