The freeze/thaw stability of this material in solution has not been investigate. In general, cyclodextrins are used to enhance the water solubility of hydrophobic compounds. The majority of these compounds will lose potency or demonstrate degradation with repeated freeze/thaw cycles. Please see the link below to review this product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/389/483/h107dat.pdf
H107
(2-Hydroxypropyl)-β-cyclodextrin
powder
Synonym(s):
2-hydroxypropylether, Beta-cyclodextrin
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5 G
$191.00
5 X 5 G
$656.00
100 G
$1,340.00
About This Item
CAS Number:
EC Number:
UNSPSC Code:
12352201
PubChem Substance ID:
NACRES:
NA.77
form:
powder
assay:
≥98% (TLC)
Recommended Products
biological source
synthetic (organic)
Quality Level
assay
≥98% (TLC)
form
powder
mol wt
estimated mol wt ~1396 Da
solubility
H2O: soluble
storage temp.
room temp
SMILES string
CC(O)COCC1OC2OC3C(COCC(C)O)OC(OC4C(COCC(C)O)OC(OC5C(COCC(C)O)OC(OC6C(COCC(C)O)OC(OC7C(COCC(C)O)OC(OC8C(COCC(C)O)OC(OC1C(OCC(C)O)C2OCC(C)O)C(OCC(C)O)C8OCC(C)O)C(OCC(C)O)C7OCC(C)O)C(OCC(C)O)C6OCC(C)O)C(OCC(C)O)C5OCC(C)O)C(OCC(C)O)C4OCC(C)O)C(OCC(C)O)C3OCC(C)O
InChI
1S/C63H112O42/c1-22(64)8-85-15-29-50-36(71)43(78)57(92-29)100-51-30(16-86-9-23(2)65)94-59(45(80)38(51)73)102-53-32(18-88-11-25(4)67)96-61(47(82)40(53)75)104-55-34(20-90-13-27(6)69)98-63(49(84)42(55)77)105-56-35(21-91-14-28(7)70)97-62(48(83)41(56)76)103-54-33(19-89-12-26(5)68)95-60(46(81)39(54)74)101-52-31(17-87-10-24(3)66)93-58(99-50)44(79)37(52)72/h22-84H,8-21H2,1-7H3/t22?,23?,24?,25?,26?,27?,28?,29-,30-,31?,32?,33?,34?,35?,36?,37-,38?,39-,40+,41+,42+,43?,44+,45?,46+,47+,48+,49+,50+,51+,52-,53-,54-,55-,56-,57+,58-,59+,60-,61-,62-,63-/m1/s1
InChI key
ODLHGICHYURWBS-RYJYQAAZSA-N
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General description
Average degree of substitution is 0.5-1.3 unit of 2-hydroxypropyl (C3H7O) per glucose unit
Cyclodextrins are cyclic oligosaccharides consisting of 6, 7, or 8 glucopyranose units, usually referred to as α-, β-, or γ-cyclodextrins, respectively. These compounds have rigid doughnut-shaped structures making them natural complexing agents. The unique structures of these compounds owe their stability to intramolecular hydrogen bonding between the C2- and C3-hydroxyl groups of neighboring glucopyranose units. The molecule takes on the shape of a torus with the C2- and C3-hydroxyls located around the larger opening and the more reactive C6-hydroxyl aligned around the smaller opening. The arrangement of C6-hydroxyls opposite the hydrogen bonded C2- and C3-hydroxyls forces the oxygen bonds into close proximity within the cavity, leading to an electron rich, hydrophobic interior. The size of this hydrophobic cavity is a function of the number of glucopyranose units forming the cyclodextrin.
The solubility of natural cyclodextrins is very poor. In the late 1960′s, it was discovered that chemical substitutions at the 2, 3, and 6 hydroxyl sites would greatly increase solubility. Most chemically modified cyclodextrins are able to achieve a 50% (w/v) concentration in water.
Cavity size is the major determinant as to which cyclodextrin is used in complexation. The cavity diameter of β-cyclodextrins or β-glucopyranose unit compounds is well-suited for use with molecules the size of hormones, vitamins and many compounds frequently used in tissue and cell culture applications. For this reason, ß-cyclodextrin is most commonly used as a complexing agent.
The solubility of natural cyclodextrins is very poor. In the late 1960′s, it was discovered that chemical substitutions at the 2, 3, and 6 hydroxyl sites would greatly increase solubility. Most chemically modified cyclodextrins are able to achieve a 50% (w/v) concentration in water.
Cavity size is the major determinant as to which cyclodextrin is used in complexation. The cavity diameter of β-cyclodextrins or β-glucopyranose unit compounds is well-suited for use with molecules the size of hormones, vitamins and many compounds frequently used in tissue and cell culture applications. For this reason, ß-cyclodextrin is most commonly used as a complexing agent.
Application
(2-Hydroxypropyl)-β-cyclodextrin has been used:
The solubility of lipophilic drugs increases linearly with the concentration of hydroxypropyl-β-cyclodextrin (HBC) in aqueous solution because of the complex between HBC and the drug. This guest-host type complex is formed between the drug and the non-polar cavity in the HBC that results in enhanced solubility. Solutions may be lyophilized to produce freely soluble powders. Non-toxic in rabbits and mice.
Comparable product
Product No.
Description
Pricing
Replaced by
Product No.
Description
Pricing
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Articles
Cyclodextrin solubilizes fat-soluble vitamins and hormones, enhancing their solubility in water for cell culture applications.
Techniques for solubilizing metabolically important compounds in aqueous solutions are reviewed.
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When I repeatedly freeze and melt a stock solution made by melting 2-HCD in H2O, how long is the stability guaranteed?
1 answer-
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Können Sie mir mitteilen welche Qualität das angebotene Produkt besitzt? Handelt es sich um Ph.Eur. Qualität oder zumindest USP Ware?
1 answer-
This product is intended for research use only and is assigned a Quality Level of 300. Please see the link below to review product 1.42020, Cyclodextrin HPB, which is suitable for pharmaceutical use.
https://www.sigmaaldrich.com/product/mm/142020The Quality Level for each product is listed in the 'PROPERTIES' section of the product page. Products showing a Quality Level of 500 - 600 are generally suitable for Pharmaceutical Manufacturing. Further details regarding the M-Clarity Quality program may be reviewed at the link below:
https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/m-clarity-programHelpful?
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