G4535

[D-Lys³]-GHRP-6

synthetic, lyophilized powder

• Synonym(s): [His¹, D-Lys³, Lys⁶]-GHRP, His-D-Trp-D-Lys-Trp-D-Phe-Lys-NH₂, [D-Lys³]-Growth Hormone Releasing Peptide 6
• MDL number: MFCD00214665
• UNSPSC Code: 12352209
• PubChem Substance ID: 329799930
• NACRES: NA.32

Properties

• biological source: synthetic
• Quality Level: 200
• form: lyophilized powder
• UniProt accession no.: P01286
• storage temp.: −20°C
• SMILES string: NCCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@@H](N)Cc6c[nH]cn6)C(N)=O
• InChI: 1S/C49H63N13O6/c50-20-10-8-18-39(44(53)63)58-47(66)41(22-30-12-2-1-3-13-30)61-49(68)43(24-32-27-56-38-17-7-5-15-35(32)38)62-46(65)40(19-9-11-21-51)59-48(67)42(23-31-26-55-37-16-6-4-14-34(31)37)60-45(64)36(52)25-33-28-54-29-57-33/h1-7,12-17,26-29,36,39-43,55-56H,8-11,18-25,50-52H2,(H2,53,63)(H,54,57)(H,58,66)(H,59,67)(H,60,64)(H,61,68)(H,62,65)/t36-,39-,40+,41+,42+,43-/m0/s1
• InChI key: MGSNWNLPMHXGDD-DFWOJPNQSA-N
• Gene Information: human ... GHRH(2691)

Description

Amino Acid Sequence

His-Trp-Lys-Trp-Phe-Lys-NH2

General description

[D-Lys³]-GHRP6 (growth hormone releasing peptide 6) is a synthetic analog of the orexigenic peptide hormone called ghrelin.

Application

[D-Lys3]-GHRP-6 has been used:

• to study its role in incretin dysfunction and hyperglycemia in cystic fibrosis
• as an antagonist of growth hormone secretagogue receptor (GHS-R)
• as ghrelin receptor antagonist to study the dose-dependent effects of intraduodenal ghrelin on the glucose infusion rate (GIR) during pancreatic-euglycemic clamp procedure (PECs)

[D-Lys³]-GHRP6 has been used-

• to treat bovine somatotropes to determine the release of GH from treated cells and non-treated or control cells
• for intraperitoneal injection to groups of broiler chicken to determine the effect on feed intake, weight gain, and feed conversion ratio

Biochem/physiol Actions

[D-Lys3]-GHRP-6, a selective growth-hormone secretagogue receptor (GHSR) antagonist displays pro-autophagic effects on skeletal muscle. It can be used to study the dependency of GHSR-1a signalling mediated by acylated ghrelin.

[D-Lys³]-GHRP6 (growth hormone releasing peptide 6) induces the secretion of growth hormone (GH). In the membrane of clonal GC somatotropes, this peptide elevates the number of functional voltage-gated Ca²⁺ and Na⁺ channels. Chronic treatment with this peptide causes an elevation in Na+ macroscopic current in bovine pituitary somatotropes in culture, which results in an increase in the release of GH.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)