G1639

D-(+)-Galactosamine hydrochloride

BioReagent, suitable for cell culture

• Synonym(s): 2-Amino-2-deoxy-D-galactopyranose hydrochloride, D-Chondrosamine hydrochloride
• Empirical Formula (Hill Notation): C₆H₁₃NO₅ · HCl
• CAS Number: 1772-03-8
• Molecular Weight: 215.63
• Beilstein/REAXYS Number: 3697825
• EC Number: 217-198-1
• MDL number: MFCD00135830
• UNSPSC Code: 12352209
• PubChem Substance ID: 24895072
• NACRES: NA.75

Properties

• biological source: fish cartilage (shark)
• Quality Level: 200
• product line: BioReagent
• assay: ≥99%
• technique(s): cell culture | mammalian: suitable
• impurities: Glucosamine, essentially free
• solubility: water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow
• shipped in: ambient
• storage temp.: room temp
• SMILES string: Cl.N[C@@H](C=O)[C@@H](O)[C@@H](O)[C@H](O)CO
• InChI: 1S/C6H13NO5.ClH/c7-3(1-8)5(11)6(12)4(10)2-9;/h1,3-6,9-12H,2,7H2;1H/t3-,4+,5+,6-;/m0./s1
• InChI key: CBOJBBMQJBVCMW-NQZVPSPJSA-N

Description

application

D-(+)-Galactosamine hydrochloride has been used to:

• induce livery injury[1]
• inflammatory liver injury[2]
• acute liver failure (ALF)[3] in mice

Biochem/physiol Actions

Galactosamine (D-GalN) is synthesized from galactose and is potential hepatotoxic agent. D-GalN in combination with lipopolysaccharide leads to the development of lethal liver injury and hepatic failure.[4] It sensitizes cells to the toxic effects of the cytokine in particular the tumor necrosis factor(TNF).[5]

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)