IgG antibody subtype is the most abundant serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids.
There are four classes of IgG namely IgG1, IgG2, IgG3, and IgG4. Among them IgG1 is the most abundant antibody.
Specificity
Binds all rabbit Igs.
Immunogen
Purified rabbit IgG
Application
Anti-Rabbit IgG (whole molecule)-FITC antibody produced in goat has been used in immunohistochemistry and indirect immunofluorescence.
Biochem/physiol Actions
Immunoglobulin G (IgG) provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defense of the neonate against infections. IgG1 deficiency results in hypogammaglobulinemia. IgG2 deficiency increases susceptibility to bacterial infections IgG3 mediates effector functions IgG4 are associated with asymptomatic infection. IgG antibody have enormous therapeutic potential and the Fc region is involved for the development of therapeutic antibody.
Other Notes
Antibody adsorbed with human IgG.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, with 15 mM sodium azide as a preservative.
Preparation Note
Adsorbed to reduce background staining with human samples.
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