F9052

Anti-FRS2 (SNT-1) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-FRS1A, Anti-FRS2A, Anti-FRS2alpha, Anti-SNT, Anti-SNT-1, Anti-SNT1
• MDL number: MFCD03791556
• UNSPSC Code: 51111800
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 92-95 kDa (doublet)
• species reactivity: rat, mouse, human
• technique(s): immunoprecipitation (IP): 10-20 μg using RIPA lysate of mouse NIH/3T3 cells; microarray: suitable; western blot: 1:1,000 using whole cell extracts of rat PC-12 cells or human HepG2 cells
• UniProt accession no.: Q8WU20
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... FRS2(10818) ; mouse ... Frs2(327826) ; rat ... Frs2(314850)

Description

General description

Fibroblast growth factor receptor substrate 2 (FRS2), also known as suc-1 associated neurotrophic factor target protein (SNT) exist in two structurally similar forms namely, FRS2a (SNT-1) and FRS-2b (SNT-2). FRS2 is characterized with a consensus myristylation sequence, involved in its recruitment to the cell membrane 4 and a putative phosphotyrosine binding (PTB) domain in its amino-terminus.

Immunogen

synthetic peptide corresponding to human FRS2 sequence, (amino acids 487-505). The corresponding sequence is identical in Xenopus and differs from the respective human and mouse FRS2β sequences by 2 and 3 amino acids, respectively.

Biochem/physiol Actions

Fibroblast growth factors (FGF) receptor substrate (FRS) functions as a lipid-anchored docking protein that is tyrosine phosphorylated and recruited to FGFR upon FGF stimulation. fibroblast growth factor receptor substrate 2 (FRS2) plays an important role in linking fibroblast growth factor (FGF) and nerve growth factor (NGF) with the Ras/ mitogen-activated protein kinases (MAPKs) signaling pathway, thus relaying information from the cell surface to the nucleus. FRS2 proteins are tyrosine phosphorylated in response to activation of the RET receptor, a tyrosine kinase that functions as the signal transducing receptor for the glial cell line-derived neurotrophic factor (GDNF).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable