F1168
Fibroblast Growth Factor-9 human
recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture, ≥97% (SDS-PAGE)
Synonym(s):
hGFG-9, FGF-9, GAF, Glial Activating Factor
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About This Item
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biological source
human
Quality Level
recombinant
expressed in baculovirus infected Sf21 cells
assay
≥97% (SDS-PAGE)
form
lyophilized powder
potency
2.6 ng/mL
mol wt
~25 kDa
packaging
pkg of 25 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... FGF9(2254)
General description
FGF9 (fibroblast growth factor 9) is a member of the FGF family, which consists of a minimum of 24 members. This protein is highly conserved across species, and the gene is localized to human chromosome 13q11-q12. In embryos, FGF9 mRNA has a ubiquitous expression pattern. In adults, this protein has a limited range of expression in normal conditions, and expression is usually restricted to brain, kidney and uterus.
Application
FGF9 (fibroblast growth factor 9) has been used for the culture of embryonic Sertoli cells obtained from E14.5 testes.
Biochem/physiol Actions
FGF9 (fibroblast growth factor 9) is expressed in the epithelium and mesothelium of developing lung in the pseudoglandular stage. In developing lungs, it regulates the branching of epithelium, proliferation of mesenchymal cells, and expansion of the lungs. It is overexpressed in patients with idiopathic pulmonary fibrosis (IPF), in regions demonstrating active cell hyperplasia, metaplasia and fibrosis. Thus, it might facilitate the pathogenesis of IPF. The expression of this protein is up-regulated in colon cancer, which is an outcome of hypoxia-induced translational activation.
Mitogenic for glial cells, fibroblasts, and oligodendrocyte type 2 astrocyte progenitor cells; not mitogenic for endothelial cells. Like aFGF and bFGF, FGF-9 has no secretory signal sequence.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 1.25 mg bovine serum albumin.
Analysis Note
The biological activity is measured in a bioassay using BALB/3T3 cells.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificates of Analysis (COA)
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Tsung-Ming Chen et al.
Nucleic acids research, 42(5), 2932-2944 (2013-12-18)
Human fibroblast growth factor 9 (FGF9) is a potent mitogen involved in many physiological processes. Although FGF9 messenger RNA (mRNA) is ubiquitously expressed in embryos, FGF9 protein expression is generally low and restricted to a few adult organs. Aberrant expression
Fibroblast growth factors (FGFs).
Vainikka, S., et al. et al.
Guidebook to Cytokines and Their Receptors, 214-214 (1994)
Louise Willerton et al.
The International journal of developmental biology, 48(7), 637-643 (2004-10-08)
Proliferation and cord formation by embryonic Sertoli cells are pivotal events involved in testis morphogenesis. A number of growth factors have been implicated in mediating these events. However, the exact level of involvement and importance of each as yet remains
Emily Coffey et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 61(9), 671-679 (2013-06-26)
The fibroblast growth factor (FGF) family of signaling ligands contributes significantly to lung development and maintenance in the adult. FGF9 is involved in control of epithelial branching and mesenchymal proliferation and expansion in developing lungs. However, its activity and expression
M Miyamoto et al.
Molecular and cellular biology, 13(7), 4251-4259 (1993-07-01)
Glia-activating factor (GAF) is a novel heparin-binding growth factor purified from the culture supernatant of a human glioma cell line. It shows a spectrum of activity slightly different from those of other known growth factors. We have isolated the cDNA
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