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About This Item
Empirical Formula (Hill Notation):
C43H65N7O9
CAS Number:
Molecular Weight:
824.02
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
assay
≥97% (HPLC)
storage temp.
−20°C
SMILES string
CCCCC(NC=O)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCC)C(=O)NC(Cc2ccc(O)cc2)C(=O)NC(CCCCN)C(O)=O
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Biochem/physiol Actions
Potent chemoattractant for human neutrophils.
Radioiodinated molecule has full biological activity.
Radioiodinated molecule has full biological activity.
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificates of Analysis (COA)
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L A Sklar et al.
Proceedings of the National Academy of Sciences of the United States of America, 78(12), 7540-7544 (1981-12-01)
Antifluorescein antibody molecules were used to interrupt the stimulation of neutrophils by a fluoresceinated chemotactic peptide. From the results we construct a semiquantitative relationship among ligand-receptor interaction, the time course of cell triggering and response, and aspects of cellular adaptation.
V Radhika et al.
American journal of hematology, 52(3), 155-164 (1996-07-01)
Binding of chemoattractant to polymorphonuclear leukocytes (PMNL) triggers a series of events like polymerization of actin and tubulin, orientation of cells, chemotaxis, increase in fluid pinocytosis and phagocytosis, and stimulation of microbicidal pathways which includes lysosomal degranulation and generation of
V Niggli et al.
European journal of pharmacology, 335(1), 43-52 (1997-11-26)
To define a possible role of the enzyme phosphatidylinositol 3-kinase (PI 3-kinase) in motile functions of neutrophils, we have used a potent inhibitor of this enzyme, [1S-(1alpha,6b alpha,9a beta,11alpha,11bbeta)]-1-(acetyloxy)-1,6b,7,8,9a,10,11 ,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno [4,5-h]-2-benzopyran-3,6,9-trione (wortmannin). Wortmannin markedly attenuated chemotactic peptide-induced development of polarity
J Niedel
The Journal of biological chemistry, 256(17), 9295-9299 (1981-09-10)
The formyl peptide chemotactic receptor has been solubilized by digitonin treatment of purified human neutrophil membranes. Of several potential assay methods tested for their ability to separate receptor-bound from free ligand, only gel filtration through an acrylamide cross-linked agarose matrix
G Vaidyanathan et al.
Nuclear medicine and biology, 22(6), 759-764 (1995-08-01)
A potent chemotactic peptide, formyl-norleucyl-leucyl-phenylalanyl-norleucyl-tyrosyl-lysine was derivatized by reaction with N-succinimidyl 4-fluorobenzoate. This derivatized peptide bound to human polymorphonuclear leukocytes in vitro and exhibited biological activity in a superoxide production assay. Peptide labeling using N-succinimidyl 4-[18F]fluorobenzoate was accomplished in reasonable
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