D9315

Deltamethrin

≥98%

• Empirical Formula (Hill Notation): C₂₂H₁₉Br₂NO₃
• CAS Number: 52918-63-5
• Molecular Weight: 505.20
• Beilstein/REAXYS Number: 6746312
• EC Number: 258-256-6
• MDL number: MFCD00870122
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724471
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98%
• form: solid
• Storage temp.: −20°C
• SMILES string: CC1(C)[C@@H](\C=C(\Br)Br)[C@H]1C(=O)O[C@H](C#N)c2cccc(Oc3ccccc3)c2
• InChI: 1S/C22H19Br2NO3/c1-22(2)17(12-19(23)24)20(22)21(26)28-18(13-25)14-7-6-10-16(11-14)27-15-8-4-3-5-9-15/h3-12,17-18,20H,1-2H3/t17-,18+,20-/m0/s1
• Inchi Key: OWZREIFADZCYQD-NSHGMRRFSA-N

Description

Application

Deltamethrin has been used to study its effect:

• as a PP2A/PPP3CA inhibitor by treating HEK293 (human embryonic kidney cells) Tau-BiFC cells[1]
• on the innate immunity in rainbow trout[2]
• on the molecular stress level in black tiger shrimp Penaeus monodon[3]

Biochem/physiol Actions

Deltamethrin is a type II semi-synthetic pyrethrin, which acts as a potent inhibitor of calcineurin (protein phosphatase 2B) and has an IC₅₀ of about 100 pM.[4] This inhibitory action results in cellular hyperexcitability by causing non-mutated calcium channels to remain open for an extended period of time allowing an abundance of Ca²⁺ to enter the cell. Some sodium channel mutations such as the L993F mutation in Xenopus oocytes show decreased sensitivity to deltamethrin.[5]

Safety Information

• Pictograms: GHS06,GHS09
• signalword: Danger
• hcodes: H301 + H331,H410
• pcodes: P261 - P264 - P271 - P273 - P301 + P310 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: 212.0 °F - closed cup
• flash_point_c: 100 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges