D7071

Dapoxetine hydrochloride

≥98% (HPLC)

• Synonym(s): (S)-N,N-dimethyl-1-phenyl-3-(1-naphthalenyloxy)propanamine hydrochloride, S-(+)-N,N-dimethyl-a-[2-(naphthalenyloxy)ethyl] benzenemethanamine hydrochloride, LY-210448 hydrochloride
• Empirical Formula (Hill Notation): C₂₁H₂₃NO · HCl
• CAS Number: 129938-20-1
• Molecular Weight: 341.87
• MDL number: MFCD08272809
• UNSPSC Code: 12352200
• PubChem Substance ID: 329798842
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D +125 to +135°, c = 1 in methanol
• storage condition: desiccated
• color: white
• solubility: DMSO: ≥20 mg/mL
• originator: Eli Lilly
• storage temp.: room temp
• SMILES string: Cl.CN(C)[C@@H](CCOc1cccc2ccccc12)c3ccccc3
• InChI: 1S/C21H23NO.ClH/c1-22(2)20(18-10-4-3-5-11-18)15-16-23-21-14-8-12-17-9-6-7-13-19(17)21;/h3-14,20H,15-16H2,1-2H3;1H/t20-;/m0./s1
• InChI key: IHWDIQRWYNMKFM-BDQAORGHSA-N
• Gene Information: human ... SLC6A4(6532)

Description

General description

Dapoxetine ((+)-(S)-N,N-dimethyl-(α)-[2(1naphthal enyloxy)ethyl]-benzenemethanamine hydrochloride) possess a similar structure as that of fluoxetine.

Biochem/physiol Actions

Dapoxetine is capable of blocking recombinant Kv4.3 potassium voltage-gated channels. It is considered as safe.

Potent Selective serotonin reuptake inhibitor (SSRI); used in treatment of premature ejaculation

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H319,H413
• pcodes: P264 - P273 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable