D3566

Anti-DcR1 antibody produced in rabbit

~0.5 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-Decoy Receptor 1, Anti-LIT, Anti-TRAIL-R3, Anti-TRID
• UNSPSC Code: 12352203
• MDL number: MFCD01865567

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~65 kDa
• species reactivity: mouse, rat, human
• concentration: ~0.5 mg/mL
• technique(s): microarray: suitable, western blot: 0.5-1 μg/mL
• UniProt accession no.: O14798
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... TNFRSF10C(8794)

Description

General description

DcR1 is found in most normal human tissue, but not in most cancer cell lines. It is a member of the TNF family of TRAIL (TNF-related apoptosis-induced ligand) receptors.

Immunogen

synthetic peptide corresponding to amino acids 111-123 at the extracellular domain of human DcR1 precursor.

Application

Anti-DcR1 antibody produced in rabbit is suitable for immunoblotting at a working concentration of 0.5-1μg/mL using human HeLa cells and mouse and rat liver tissue lysates.

Biochem/physiol Actions

DcR1 is a glycosylphosphatidylinositol-linked membrane protein that binds TRAIL (APO2 ligand). It acts as a decoy receptor and binds TRAIL to its extracellular TRAIL-binding domain, thus inhibiting TRAIL-mediated apoptosis. It does not have an intracellular death domain and, therefore, does not induce apoptosis.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable