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D1068

Sigma-Aldrich

DCB

≥98% (HPLC), solid

Synonym(s):

3,3′-Dichlorobenzaldazine, NSC 67224

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10 MG
$116.00
50 MG
$309.00

About This Item

Empirical Formula (Hill Notation):
C14H10Cl2N2
CAS Number:
6971-97-7
Molecular Weight:
277.15
MDL number:
MFCD00556081
UNSPSC Code:
12352200
PubChem Substance ID:
24724458
NACRES:
NA.77

$116.00

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assay

≥98% (HPLC)

form

solid

storage condition

desiccated
under inert gas

color

yellow

solubility

DMSO: ~6.8 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

Clc1cccc(\C=N\N=C\c2cccc(Cl)c2)c1

InChI

1S/C14H10Cl2N2/c15-13-5-1-3-11(7-13)9-17-18-10-12-4-2-6-14(16)8-12/h1-10H/b17-9+,18-10+

InChI key

XMOVWXSCYLINBJ-BEQMOXJMSA-N

Biochem/physiol Actions

3,3′-dichlorobenzaldazine (DCB) serves as an allosteric ligand with neutral cooperativity. It helps to block the positive allosteric regulation of mGluRs (metabotropic glutamate receptor subtype 5 (mGluR5) with the help of 3,3′-difluorobenzaldazine (DFB) and the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB).[1]
Neutral allosteric modulator of the metabotropic glutamate receptor mGluR5.

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
045K4622

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