C8737
Anti-Caspr2 antibody produced in rabbit
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-Contactin-Associated Protein 2
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200 μL
$850.00
$850.00
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A recombinant, preservative-free antibody is available for your target. Try ZRB1079
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200 μL
$850.00
About This Item
conjugate:
unconjugated
application:
IHC
WB
WB
clone:
polyclonal
species reactivity:
mouse, rat, human
citations:
9
technique(s):
immunohistochemistry: suitable
western blot: 1:200 using rat brain membranes
western blot: 1:200 using rat brain membranes
$850.00
In StockDetails
A recombinant, preservative-free antibody is available for your target. Try ZRB1079
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
mol wt
antigen 180 kDa
species reactivity
mouse, rat, human
technique(s)
immunohistochemistry: suitable
western blot: 1:200 using rat brain membranes
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CNTNAP2(26047)
mouse ... Cntnap2(66797)
rat ... Cntnap2(500105)
Related Categories
General description
CASPR2 (Contactin-associated protein-like 2) belongs to CASPR family and neurexin superfamily.
Immunogen
peptide corresponding to amino acids residues 1315-1331 of human Caspr2.
application
Anti-CASPR2 antibody has been used for immunohistochemitry and western blotting of proteins from mouse brain samples. It is also suitable for western blot analysis at a dilution of 1:200 by using rat brain membranes.
Biochem/physiol Actions
CASPR2 (Contactin-associated protein-like 2) associates shaker like K+ channels in the juxtaparanodal region flanking nodes of Ranvier. It is expressed in different and distinct regions of the central nervous system (CNS) where it may plays an important role in cell recognition. CASPR and CASPR2 may interact with the actin-based cytoskeleton through cytoskeleton-associated protein 4.1B. CASPR2 is crucial for synapse formation and outgrowth of axon and dendrite. CASPR2 forms a complex with G-protein-coupled receptor 37 (GPR37) and multiple PDZ domain protein 1 (MUPP1). Disruption of the complex is linked with autism spectrum disorder (ASD). Genetic variations in CASPR2 are also associated with intellectual disability, epilepsy, schizophrenia and language disorders. It also regulates diet-induced obesity.
Physical form
Lyophilized from 0.4 mg/ml in phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose, and ≤0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Description
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Storage Class
11 - Combustible Solids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Yuko Tanabe et al.
Journal of neurochemistry, 134(4), 783-793 (2015-05-16)
Autism spectrum disorder (ASD) is a developmental brain disorder. Mutations in synaptic components including synaptic adhesion molecules have been found in ASD patients. Contactin-associated protein-like 2 (CASPR2) is one of the synaptic adhesion molecules associated with ASD. CASPR2 forms a
Betul Bakkaloglu et al.
American journal of human genetics, 82(1), 165-173 (2008-01-09)
Autism spectrum disorders (ASD) are a group of related neurodevelopmental syndromes with complex genetic etiology. We identified a de novo chromosome 7q inversion disrupting Autism susceptibility candidate 2 (AUTS2) and Contactin Associated Protein-Like 2 (CNTNAP2) in a child with cognitive
Natalia Denisenko-Nehrbass et al.
The European journal of neuroscience, 17(2), 411-416 (2003-01-25)
Caspr/paranodin, a neuronal transmembrane glycoprotein, is essential for the structure and function of septate-like paranodal axoglial junctions at nodes of Ranvier. A closely related protein, Caspr2, is concentrated in juxtaparanodal regions where it associates indirectly with the shaker-type potassium channels.
Ivo Spiegel et al.
Molecular and cellular neurosciences, 20(2), 283-297 (2002-07-03)
The NCP family of cell-recognition molecules represents a distinct subgroup of the neurexins that includes Caspr and Caspr2, as well as Drosophila Neurexin-IV and axotactin. Here, we report the identification of Caspr3 and Caspr4, two new NCPs expressed in nervous
David A Buchner et al.
Mammalian genome : official journal of the International Mammalian Genome Society, 23(7-8), 431-442 (2012-07-04)
Despite considerable effort, the identification of genes that regulate complex multigenic traits such as obesity has proven difficult with conventional methodologies. The use of a chromosome substitution strain-based mapping strategy based on deep congenic analysis overcame many of the difficulties
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