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C7499

Sigma-Aldrich

CK-548

≥98% (HPLC)

Synonym(s):

2-(3-Bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-4-thiazolidinone, CK-0993548

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About This Item

Empirical Formula (Hill Notation):
C15H11BrClNO2S
CAS Number:
388604-55-5
Molecular Weight:
384.68
MDL number:
MFCD01844273
UNSPSC Code:
12352200
PubChem Substance ID:
329775079

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

solubility

DMSO: 24 mg/mL

storage temp.

2-8°C

SMILES string

Oc1ccc(Cl)cc1N2C(SCC2=O)c3cccc(Br)c3

InChI

1S/C15H11BrClNO2S/c16-10-3-1-2-9(6-10)15-18(14(20)8-21-15)12-7-11(17)4-5-13(12)19/h1-7,15,19H,8H2

InChI key

KEGQNJITMFBVAC-UHFFFAOYSA-N

Biochem/physiol Actions

CK-548 inhibits the activity of actin-related protein (Arp)2/3 complex by inserting into the hydrophobic core of Arp3 and altering its conformation: inhibits

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H302,H400

pcodes

P273

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
026M4769V
075M4719V
070M4605V

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Renu Khasa et al.
Microbial pathogenesis, 149, 104565-104565 (2020-10-16)
Multiple membrane trafficking networks operate in the eukaryotic cell and are hijacked by viruses to establish infection. Recent studied have highlighted that viruses can exploit distinct pathways depending on the cell type. Japanese encephalitis virus (JEV), a neurotropic flavivirus, can
Renu Khasa et al.
The Journal of general virology, 100(2), 176-186 (2018-11-30)
Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, is one of the leading global causes of virus-induced encephalitis. The infectious life-cycle of viruses is heavily dependent on the host membrane trafficking network. Here, we have performed a RNA-interference-based screen using a
Arnat Balabiyev et al.
Molecular biology of the cell, 31(18), 2002-2020 (2020-06-25)
Macrophage fusion resulting in the formation of multinucleated giant cells (MGCs) is a multistage process that requires many adhesion-dependent steps and involves the rearrangement of the actin cytoskeleton. The diversity of actin-based structures and their role in macrophage fusion is
Monika Hartmann et al.
Molecular cancer research : MCR, 13(5), 879-890 (2015-02-06)
Ectodomain cleavage (shedding) of transmembrane proteins by metalloproteases (MMP) generates numerous essential signaling molecules, but its regulation is not totally understood. CD44, a cleaved transmembrane glycoprotein, exerts both antiproliferative or tumor-promoting functions, but whether proteolysis is required for this is

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