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About This Item
Linear Formula:
C18H17N6O5S2Na
CAS Number:
Molecular Weight:
484.48
EC Number:
MDL number:
UNSPSC Code:
51101500
PubChem Substance ID:
mode of action
cell wall synthesis | interferes
SMILES string
[Na+].Cn1nnnc1SCC2=C(N3C(SC2)[C@H](NC(=O)[C@H](O)c4ccccc4)C3=O)C([O-])=O
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General description
Chemical structure: ß-lactam
Application
Cefamandole is used to study antibiotic resistance, the effects of expression and inhibition of penicillin-binding proteins, and the cooperation of antibiotics with host defence mechanisms .
Cefamandole is used to study the effects of expression and inhibition of PBP 2A and other penicillin-binding proteins (PDPs) on bacterial cell wall mucopeptide synthesis.
Biochem/physiol Actions
Cefamandole, a cephalosporin antibiotic, disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. As Cefamandole is broken down in the body, it releases free N-methylthiotetrazole, which can cause hypoprothrombinemia .
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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A Andreana et al.
Antimicrobial agents and chemotherapy, 25(2), 182-186 (1984-02-01)
Our purpose was to study whether treatment of Escherichia coli with subinhibitory concentrations of either cefamandole or gentamicin could change bacterial susceptibility to the serum bactericidal effect and to the phagocytic and killing activity of the rat liver reticuloendothelial system.
Stork CM
Antibiotics, Antifungals, and Antivirals, 847-847 (2006)
T D Gootz et al.
The Journal of infectious diseases, 146(1), 34-42 (1982-07-01)
Studies were performed to characterize resistance to cefamandole in two strains of Enterobacter cloacae. Susceptible wild-type cells were exposed either to cefamandole to select stably resistant mutants or to cefoxitin to induce unstable resistance. The two types of resistant cells
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