Monoclonal Anti-Cul7 (mouse IgG2b isotype) is derived from the hybridoma Ab38 produced by the fusion of mouse myeloma cells (P3X63Ag8.653) and splenocytes from BALB/c mice immunized with mouse Cul7. CUL7 is expressed in all tissues and cell lines except testis and small intestine.
Immunogen
mouse Cul7.
Application
Monoclonal Anti-Cul7 antibody produced in mouse is suitable for immunoprecipitation and western blotting at a concentration of 0.5-1μg/mL using 3T3 total cel extract.
Biochem/physiol Actions
CUL7 functions to promote cell growth through and antagonizes the function of p53.
Cullin-7 (cul7) is a protein encoded by the CUL7 gene in humans. It is also referred as 3M1, KIAA0076 and dJ20C7.5. Mutation in CUL7 gene is majorly responsible for 3M syndrome (is a rare autosomal recessive disorder). CUL7 acts as a novel gene potentially involved in liver carcinogenesis associated with metabolic syndrome (MS) and its amplification may influence cell proliferation.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Italian journal of pediatrics, 39, 21-21 (2013-03-23)
3-M syndrome is a rare autosomal recessive disorder that causes short stature, unusual facial features and skeletal abnormalities. Mutations in the CUL7, OBSL1 and CCDC8 genes could be responsible for 3-M syndrome.Here we describe the growth and evolution of dismorphic
Fibrosis is a pathognomonic feature of structural heart disease and counteracted by distinct cardioprotective mechanisms, e.g. activation of the phosphoinositide 3-kinase (PI3K) / AKT pro-survival pathway. The Cullin-RING E3 ubiquitin ligase 7 (CRL7) was identified as negative regulator of PI3K/AKT
European journal of human genetics : EJHG, 17(3), 395-400 (2009-02-20)
The 3M syndrome is a rare autosomal recessive disorder recently ascribed to mutations in the CUL7 gene and characterized by severe pre- and postnatal growth retardation. Studying a series of 33 novel cases of 3M syndrome, we have identified deleterious
Best practice & research. Clinical endocrinology & metabolism, 25(1), 143-151 (2011-03-15)
3M syndrome (MIM 273750) is an autosomal recessive disorder characterized by pre- and post-natal growth retardation (<-4 SD), facial dysmorphism, large head circumference, normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies. There
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