Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

C1307

Sigma-Aldrich

Cyclo(D-Glu-Ala-D-allo-Ile-Leu-D-Trp)

≥97% (HPLC)

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C31H44N6O7
CAS Number:
136553-74-7
Molecular Weight:
612.72
MDL number:
MFCD00144248
UNSPSC Code:
12352200
PubChem Substance ID:
24892400

assay

≥97% (HPLC)

form

solid

composition

Peptide content, >60%

storage temp.

−20°C

SMILES string

CCC(C)C1NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(CC(C)C)NC1=O

InChI

1S/C31H44N6O7/c1-6-17(4)26-31(44)36-23(13-16(2)3)29(42)35-24(14-19-15-32-21-10-8-7-9-20(19)21)30(43)34-22(11-12-25(38)39)28(41)33-18(5)27(40)37-26/h7-10,15-18,22-24,26,32H,6,11-14H2,1-5H3,(H,33,41)(H,34,43)(H,35,42)(H,36,44)(H,37,40)(H,38,39)

InChI key

UMKHUVRCCMAOBN-UHFFFAOYSA-N

Biochem/physiol Actions

Selective ETA endothelin receptor antagonist.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
025H04581
082H05921

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

T Hiramatsu et al.
Circulation, 92(9 Suppl), II400-II404 (1995-11-01)
Prior studies suggest an important role for coronary endothelium in ischemia/reperfusion (I/R) injury. Decreased endothelial release of the vasodilator nitric oxide occurs after I/R, but the role of the endothelium-derived vasoconstrictor endothelin-1 (ET-1) in I/R is unknown. We measured plasma
N Syed et al.
The Journal of urology, 159(2), 563-566 (1998-07-02)
Endothelin-1 (ET-1), a peptide produced by the vascular endothelium, causes profound renal vasoconstriction by binding to ET-A receptors. The present study examined the renal actions of ET-1 after ET-A receptors were blocked by BE-18257B to unmask the functions of ET-B
T Satoh et al.
FEBS letters, 310(1), 83-87 (1992-09-21)
Computer-aided molecular modelling of the endothelin (ET-A) receptor antagonists, BQ-123 and BE-18257B, shows that they have very similar 3D structures. Parts of their 3D structures are also shown to match closely with that reported for residues 6-8 in endothelin-1. On
[Agonists and antagonists to endothelin receptors].
M Ihara et al.
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 38(11), 1827-1840 (1993-08-01)
M Ihara et al.
Biochemical and biophysical research communications, 178(1), 132-137 (1991-07-15)
A competitive endothelin (ET) antagonist, BE-18257B, was isolated from the fermentation products of Streptomyces misakiensis. It is a novel cyclic pentapeptide, cyclo(-D-Glu-L-Ala-allo-D-Ile-L-Leu-D-Trp-), and binds to ETA receptors (ET-1 selective) in cardiovascular tissues, but not to ETB receptors (equally sensitive to
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service