This product is classified at an MQ 200 level. We are unable to provide the analytical method for products classified below an MQ 400. However, general conditions may be shared.
Sample Concentration - 50 mg/ml
Solvent - Chloroform
Detection - Stahl's 214
Markers - Linoleic acid and Linoleic acid methyl ester
C0563
Cardiolipin sodium salt from bovine heart
≥97% (TLC), lyophilized powder
Synonym(s):
Diphosphatidylglycerol
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10 MG
$74.40
25 MG
$123.00
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$409.00
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$1,340.00
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10 MG
$74.40
25 MG
$123.00
100 MG
$409.00
500 MG
$1,340.00
About This Item
Recommended Products
biological source
bovine heart
Quality Level
assay
≥97% (TLC)
form
lyophilized powder
lipid type
phosphoglycerides
shipped in
ambient
storage temp.
−20°C
General description
Cardiolipin is localized in the inner membrane of mitochondria. It contains 18 carbon atoms, 3-phosphatidyl groups connected via a glycerol bridge. Cardiolipin is an important component of ATP synthase enzyme.[1]
Application
Cardiolipin sodium salt from bovine heart has been used:
- as a phospholipid standard in thin layer chromatography for the quantification of total mitochondrial lipids of Neurospora crassa(89)
- as an internal standard in reverse phase high performance liquid chromatography (RP-HPLC) for quantification of bacterial lipid extracts(90)
- as an antigen to evaluate IgM reaction in systemic lupus erythematosus (SLE) patients(91)
Biochem/physiol Actions
Cardiolipin is a mitochondrial phospholipid that is found in mammalian tissues in low concentrations. It is often a membrane component. Inhibits cell attachment of fibronectin, vitronectin and Type I collagen.
Packaging
packaged under argon
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Lu Luo et al.
The Journal of biological chemistry, 289(46), 31708-31718 (2014-10-08)
Bax is a pro-apoptotic Bcl-2 family protein. The activated Bax translocates to mitochondria, where it forms pore and permeabilizes the mitochondrial outer membrane. This process requires the BH3-only activator protein (i.e. tBid) and can be inhibited by anti-apoptotic Bcl-2 family
Ze-Wei Ma et al.
Acta pharmacologica Sinica, 39(6), 1012-1021 (2017-12-22)
Humanin (HN) is a 24-residue peptide identified from the brain of a patient with Alzheimer's disease (AD). HN has been found to protect against neuronal insult caused by Aβ peptides or transfection of familial AD mutant genes. In order to
Analysis of mutations in Neurospora crassa ERMES components reveals specific functions related to beta-barrel protein assembly and maintenance of mitochondrial morphology
Wideman JG, et al.
PLoS ONE, 8(8), e71837-e71837 (2013)
Sonia Rebollo-Ramirez et al.
Chemical research in toxicology, 31(8), 688-696 (2018-06-28)
Antimicrobial resistance is a major threat the world is currently facing. Development of new antibiotics and the assessment of their toxicity represent important challenges. Current methods for addressing antibiotic toxicity rely on measuring mitochondrial damage using ATP and/or membrane potential
Val A Fajardo et al.
Scientific reports, 7(1), 2060-2060 (2017-05-19)
Cardiolipin (CL) is a unique mitochondrial phospholipid that, in skeletal muscle, is enriched with linoleic acid (18:2n6). Together, CL content and CL 18:2n6 composition are critical determinants of mitochondrial function. Skeletal muscle is comprised of slow and fast fibers that
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According to your COA for item C0563, Cardiolipin protein, the purity was tested by TLC; what are the specific test methods and experimental conditions?
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