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B7545

Sigma-Aldrich

UK 14,304

Synonym(s):

5-Bromo-N-(2-imidazolin-2-yl)-6-quinoxalinamine, 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine, Brimonidine

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About This Item

Empirical Formula (Hill Notation):
C11H10BrN5
CAS Number:
59803-98-4
Molecular Weight:
292.13
MDL number:
MFCD00153878
UNSPSC Code:
12352204

storage temp.

2-8°C

SMILES string

Brc1c(NC2=NCCN2)ccc3nccnc13

InChI

1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17)

InChI key

XYLJNLCSTIOKRM-UHFFFAOYSA-N

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Biochem/physiol Actions

Selective and potent α2 adrenoceptor agonist; also binds to noradrenergic imidazoline receptors.[1]

replaced by

Product No.
Description
Pricing

U104

UK 14,304

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Certificates of Analysis (COA)

Lot/Batch Number
066H4085
059H4069

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H Itoh et al.
Journal of cardiovascular pharmacology, 20(1), 1-6 (1992-07-01)
Endothelin-1 (ET-1) caused a concentration-dependent contraction of helical strips from rat pulmonary arteries. Removal of endothelial cells did not change the response to ET-1. ET-1 (10(-8) M) induced a small contraction of the arterial strips in the absence of extracellular
Eman S Elzanfaly et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 95, 188-192 (2012-05-29)
A new method significantly advantageous over the conventional spectrophotometric methods regarding simplicity, minimal data processing and applicability was developed. The new method is based on the fact that isoabsorptive points whenever present in an absorption spectrum will be retained even
K Benkali et al.
The British journal of dermatology, 171(1), 162-169 (2014-02-11)
Persistent facial erythema is the most common primary pathological feature of rosacea, the only treatment for which is brimonidine tartrate (BT) gel. To assess the relative bioavailability of topical BT gel in comparison with the ophthalmic BT solution. A pharmacokinetic
L Jay Katz et al.
Current medical research and opinion, 28(5), 781-788 (2012-03-31)
To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of fixed-combination brimonidine 0.2%-timolol 0.5% compared with latanoprost 0.005% in patients with glaucoma or ocular hypertension. This was a prospective, randomized, multicenter, investigator-masked clinical trial. After washout of any previous IOP-lowering
Carlos A Jiménez-Rivera et al.
The European journal of neuroscience, 35(9), 1406-1415 (2012-05-09)
The ventral tegmental area (VTA) forms part of the mesocorticolimbic system and plays a pivotal role in reward and reinforcing actions of drugs of abuse. Glutamate transmission within the VTA controls important aspects of goal-directed behavior and motivation. Noradrenergic receptors
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