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B2656

Sigma-Aldrich

Benextramine tetrahydrochloride

≥75% (HPLC), solid

Synonym(s):

BHC, Dithiobis(N-[N-(2-methoxybenzyl)-6-aminohexyl]-2-aminoethane), Dithiobis(N-[N-(2-methoxybenzyl)-6-aminohexyl]-2-aminoethane);, N,N′′-(Dithiodi-2,1-ethanediyl)bis[N′-(2-methoxyphenylmethyl)-1,6-hexanediamine] dihydrochloride, N,N′-Bis(6-[o-Methoxybenzylamino]hexyl)cystamine, N,N′-Bis(6-[o-methoxybenzylamino]hexyl)cystamine

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About This Item

Empirical Formula (Hill Notation):
C32H54N4O2S2 · 4HCl
CAS Number:
68535-69-3
Molecular Weight:
736.77
EC Number:
271-296-9
MDL number:
MFCD00012486
UNSPSC Code:
12352103

assay

≥75% (HPLC)

form

solid

color

white

solubility

H2O: soluble (Aqueous solutions are stable for at least one week at −20°C)
ethanol: soluble (warm)
methanol: soluble

storage temp.

2-8°C

SMILES string

Cl.COc1ccccc1CNCCCCCCNCCSSCCNCCCCCCNCc2ccccc2OC

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Biochem/physiol Actions

Adrenoceptor antagonist that differentiates between
two α adrenergic receptor subtypes by binding irreversibly at α1 adrenoceptors, but reversibly to α2 adrenoceptors. Irreversible Neuropeptide Y antagonist.

Physical form

Hygroscopic, photosensitive solid

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Certificates of Analysis (COA)

Lot/Batch Number
097H0466
072H0890
124H0801
122H0845
112H0393

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K Horike et al.
Naunyn-Schmiedeberg's archives of pharmacology, 356(6), 756-762 (1998-02-07)
Several physiological stimuli cause a rise in intracellular Ca2+ concentration ([Ca2+]i) in cardiomyocytes. This increased [Ca2+]i must be restored to physiological resting level to ensure response to further stimuli. In the present study, we examined the effect of neuropeptide Y
P H Van der Graaf et al.
European journal of pharmacology, 300(3), 211-214 (1996-04-11)
We have studied the effects of benextramine on the U46619 (11 alpha,9 alpha-epoxymethano-15S-hydroxy-prosta-5Z,13E-dienoic acid)-mediated contraction of the rat isolated small mesenteric artery. U46619 (10 nM-10 microM) produced a concentration-dependent contraction of the small mesenteric artery. The selective prostanoid TP receptor
J K Phillips et al.
British journal of pharmacology, 124(7), 1403-1412 (1998-09-02)
1. We have investigated the neurotransmitters and receptor subtypes involved in nerve-mediated vasoconstriction in small arteries of the rat hepatic mesentery. 2. A dense sympathetic innervation was demonstrated using catecholamine histochemistry and antibodies against the synaptic vesicle protein synaptophysin. 3.

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