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B0186

Sigma-Aldrich

BI-6C9

≥97% (HPLC), solid

Synonym(s):

N-[4-[(4-Aminophenyl)thio]phenyl]-4-[[(4-methoxyphenyl)sulfonyl]amino]-Butanamide

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About This Item

Empirical Formula (Hill Notation):
C23H25N3O4S2
CAS Number:
791835-21-7
Molecular Weight:
471.59
MDL number:
MFCD07784498
UNSPSC Code:
12352200
PubChem Substance ID:
24724408
NACRES:
NA.77

Quality Level

100

assay

≥97% (HPLC)

form

solid

color

off-white

solubility

DMSO: >20 mg/mL

storage temp.

−20°C

SMILES string

COc1ccc(cc1)S(=O)(=O)NCCCC(=O)Nc2ccc(Sc3ccc(N)cc3)cc2

InChI

1S/C23H25N3O4S2/c1-30-19-8-14-22(15-9-19)32(28,29)25-16-2-3-23(27)26-18-6-12-21(13-7-18)31-20-10-4-17(24)5-11-20/h4-15,25H,2-3,16,24H2,1H3,(H,26,27)

InChI key

LCFUJBSKPDPGKO-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

BI-6C9 is a tBid inhibitor and antiapoptotic.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Neurotoxicology, 49, 149-157 (2015-06-27)
Although there are few studies suggested PCP exposure induced developmental and behavioral disorders, however, the occurrence of neurotoxicity and PCP has not been firmly established. Tetrachlorobenzoquinone (TCBQ) is a reactive metabolite of environmental pollutant pentachlorophenol (PCP). To the best of
Sina Oppermann et al.
The Journal of pharmacology and experimental therapeutics, 350(2), 273-289 (2014-05-23)
Mitochondrial demise is a key feature of progressive neuronal death contributing to acute and chronic neurological disorders. Recent studies identified a pivotal role for the BH3-only protein B-cell lymphoma-2 interacting domain death antagonist (Bid) for such mitochondrial damage and delayed
Marieta B Heaton et al.
Alcoholism, clinical and experimental research, 39(1), 55-63 (2015-01-28)
Exposure to ethanol (EtOH) during central nervous system (CNS) development can lead to a wide array of neuroanatomical, behavioral, and cognitive abnormalities, broadly subsumed under the fetal alcohol spectrum disorder classification. One mode of EtOH-induced interference in the normal developmental
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