Skip to Content
MilliporeSigma
All Photos(4)

Documents

AV40278

Sigma-Aldrich

Anti-FUS antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-FUS-CHOP, Anti-FUS1, Anti-Fusion (involved in t(12;16) in malignant liposarcoma), Anti-TLS

Sign Into View Organizational & Contract Pricing
All Photos(4)

About This Item

UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

mol wt

53 kDa

species reactivity

mouse, rabbit, rat, human, bovine

concentration

0.5 mg - 1 mg/mL

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_004951

UniProt accession no.

P35637

storage temp.

−20°C

Gene Information

human ... FUS(2521)

General description

Fused in sarcoma (FUS); translocated in LipoSarcoma (TLS) is a component of a fusion pro-oncogene resulting from a chromosomal translocation seen in liposarcomas. FUS/TLS belongs to a sub-family of RNA binding proteins that interacts with RNA, ssDNA, and dsDNA. FUS/TLS is involved in unique functions in mRNA processing and transport, transcriptional regulation and maintenance of genomic stability. FUsed in sarcoma (FUS); Translocated in LipoSarcoma (TLS) is a multifunctional protein implicated in a wide range of cellular processes, including transcription and mRNA processing, as well as in both cancer and neurological disease. Mutations in the fused in sarcoma (FUS) gene are linked to a form of familial amyotrophic lateral sclerosis (ALS), ALS6.

Specificity

Anti-FUS/TLS polyclonal antibody reacts with chicken, bovine, human, mouse, and rat FUsed in sarcoma/translocated in LipoSarcoma proteins.

Immunogen

The immunogen for anti-FUS antibody: synthetic peptide derected towards the N terminal of human FUS

Application

Anti-FUS/TLS polyclonal antibody is used to tag FUsed in sarcoma/translocated in LipoSarcoma proteins for detection and quantitation by Western blotting and in cells and tissues by immunohistochemical (IHC) techniques. It is used as a probe to study the possible roles of FUsed in sarcoma/translocated in LipoSarcoma proteins in transcription and mRNA processing and amyotrophic lateral sclerosis, ALS6

Sequence

Synthetic peptide located within the following region: MASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGY

Physical form

Lyophilized from PBS buffer with 2% sucrose

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Francesca W van Tartwijk et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 44(27) (2024-05-02)
Aberrant condensation and localization of the RNA-binding protein (RBP) fused in sarcoma (FUS) occur in variants of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Changes in RBP function are commonly associated with changes in axonal cytoskeletal organization and branching
Nicola J Rutherford et al.
Brain research, 1524, 62-73 (2013-06-19)
Recently mutations in ubiquilin-2 were identified in patients with amyotrophic lateral sclerosis (ALS) and ALS/dementia providing direct evidence for the importance of this protein in neurodegenerative diseases. Histological studies have suggested that ubiquilin-1/-2 are associated with various pathological inclusions including

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service