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Key Documents

AV32362

Sigma-Aldrich

Anti-TLE3 antibody produced in rabbit

IgG fraction of antiserum

Synonym(s):

Anti-Transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

83 kDa

species reactivity

pig, dog, human, bovine

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_005069

UniProt accession no.

Q04726

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TLE3(7090)

General description

TLE3 is known to function as a transcriptional coregulator of adipogenesis. It interacts with HESX1 and PROP1 to regulate transcriptional expression.
Rabbit Anti-TLE3 antibody recognizes human, zebrafish, rat, mouse, and canine TLE3.

Immunogen

Synthetic peptide directed towards the N terminal region of human TLE3

Application

Rabbit Anti-TLE3 antibody can be used for western blot applications at a concentration of 2.5μg/ml.

Biochem/physiol Actions

The TLE genes are differentially expressed and encode nuclear proteins, consistent with the presence of sequence motifs associated with nuclear functions. These genes are the human homologues of Drosophila groucho, a member of the Notch signaling pathway which controls a number of different cell-fate choices in invertebrates and vertebrates.

Sequence

Synthetic peptide located within the following region: GSSSGLLALGALGSQAHLTVKDEKNHHELDHRERESSANNSVSPSESLRA

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pricing

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Luciani R Carvalho et al.
Molecular endocrinology (Baltimore, Md.), 24(4), 754-765 (2010-02-26)
Pituitary hormone deficiency causes short stature in one in 4000 children born and can be caused by mutations in transcription factor genes, including HESX1, PROP1, and POU1F1. HESX1 interacts with a member of the groucho-related gene family, TLE1, through an
Claudio J Villanueva et al.
Cell metabolism, 13(4), 413-427 (2011-04-05)
PPARγ and Wnt signaling are central positive and negative regulators of adipogenesis, respectively. Here we identify the groucho family member TLE3 as a transcriptional integrator of the PPARγ and Wnt pathways. TLE3 is a direct target of PPARγ that participates

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