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AV32307

Sigma-Aldrich

Anti-FOXC2 (AB2) antibody produced in rabbit

IgG fraction of antiserum

Synonym(s):

Anti-Forkhead box C2 (MFH-1, mesenchyme Forkhead 1)

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

54 kDa

species reactivity

human, horse, bovine

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_005242

UniProt accession no.

Q99958

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... FOXC2(2303)

General description

FOXC2 belongs to the forkhead transcription factor family and has a distinct DNA-binding forkhead domain. Increased expression of FOXC2 is known to prevent hypertriglyceridemia and insulin resistance induced by diet. FOXC2 has also been implicated in the metastasis of breast cancer.
Rabbit Anti-FOXC2 antibody recognizes human, mouse, and canine FOXC2.

Immunogen

Synthetic peptide directed towards the middle region of human FOXC2

Application

Rabbit Anti-FOXC2 can be used for western blot applications at a concentration of 1.25μg/ml.

Biochem/physiol Actions

FOXC2 belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues.

Sequence

Synthetic peptide located within the following region: VIKSEAASPALPVITKVETLSPESALQGSPRSAASTPAGSPDGSLPEHHA

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A Cederberg et al.
Cell, 106(5), 563-573 (2001-09-12)
Obesity, hyperlipidemia, and insulin resistance are common forerunners of type 2 diabetes mellitus. We have identified the human winged helix/forkhead transcription factor gene FOXC2 as a key regulator of adipocyte metabolism. Increased FOXC2 expression, in adipocytes, has a pleiotropic effect
Sendurai A Mani et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(24), 10069-10074 (2007-06-01)
The metastatic spread of epithelial cancer cells from the primary tumor to distant organs mimics the cell migrations that occur during embryogenesis. Using gene expression profiling, we have found that the FOXC2 transcription factor, which is involved in specifying mesenchymal

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