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A0207

Sigma-Aldrich

(+)-Iron(II) L-ascorbate

≥90% (titration)

Synonym(s):

L-(+)-Ascorbic acid iron(II) salt, Ferrous ascorbate, Vitamin C iron(II) salt

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About This Item

Empirical Formula (Hill Notation):
C12H14FeO12
CAS Number:
24808-52-4
Molecular Weight:
406.08
EC Number:
246-469-7
MDL number:
MFCD00137682
UNSPSC Code:
12352200
PubChem Substance ID:
24890411
NACRES:
NA.79

assay

≥90% (titration)

form

crystalline

color

dark brown

SMILES string

[H][C@@]1(OC(=O)C(O)=C1O[Fe]OC2=C(O)C(=O)O[C@]2([H])[C@@H](O)CO)[C@@H](O)CO

InChI

1S/2C6H8O6.Fe/c2*7-1-2(8)5-3(9)4(10)6(11)12-5;/h2*2,5,7-10H,1H2;/q;;+2/p-2/t2*2-,5+;/m00./s1

InChI key

RFBYLSCVRUTUSB-ZZMNMWMASA-L

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Biochem/physiol Actions

(+)-Iron(II) L-ascorbate or ferrous ascorbate has high potential to absorb iron in vivo compared to ferrous sulfate. In children, it is used as an effective oral iron supplement to treat iron deficiency anemia.
Iron-ascorbate (ferrous-ascorbate) is used as a reagent in cell culture and other systems to evaluate various aspects of oxidative stress and anti-oxidation mechanisms.

Caution

May darken in storage.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Rame Taha et al.
PloS one, 5(7), e11817-e11817 (2010-08-03)
Although mitochondrial dysfunction and oxidative stress are central mechanisms in various pathological conditions, they have not been extensively studied in the gastrointestinal tract, which is known to be constantly exposed to luminal oxidants from ingested foods. Key among these is
Ingrid Wiswedel et al.
Free radical research, 44(2), 135-145 (2010-01-22)
The aim of this study was to investigate the effect of oxidative stress on mitochondrial phospholipids. In this context, this study investigated (i) the content of phosphatidylethanolamine (PE), phosphatidylcholine (PC) and cardiolipin (CL), (ii) the correlation of CL degradation with
Dirk Hofreuter et al.
PloS one, 7(11), e50699-e50699 (2012-12-12)
Campylobacter jejuni is a major cause of food-borne disease in industrialized countries. Carbohydrate utilization by C. jejuni is severely restricted, and knowledge about which substrates fuel C. jejuni infection and growth is limited. Some amino acids have been shown to
V Marcil et al.
Clinical biochemistry, 44(10-11), 873-883 (2011-05-10)
The aims of the study were to test the susceptibility of THP-1 macrophages to develop oxidative stress and to deploy antioxidant defense mechanisms that insure the balance between the pro- and antioxidant molecules. Differentiated THP-1 were incubated in the presence
Hanne Vorwerk et al.
Molecular microbiology, 98(5), 809-830 (2015-08-12)
Thermophilic Campylobacter species colonize the intestine of agricultural and domestic animals commensally but cause severe gastroenteritis in humans. In contrast to other enteropathogenic bacteria, Campylobacter has been considered to be non-glycolytic, a metabolic property originally used for their taxonomic classification.
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