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58756

Sigma-Aldrich

1-(5-Isoquinolinesulfonyl)-3-methylpiperazine

≥98.0% (HPLC)

Synonym(s):

1-(5-Isoquinolinylsulfonyl)-3-methylpiperazine, Iso-H-7

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About This Item

Empirical Formula (Hill Notation):
C14H17N3O2S
CAS Number:
84477-73-6
Molecular Weight:
291.37
Beilstein/REAXYS Number:
5445506
MDL number:
MFCD00132900
UNSPSC Code:
12352202
PubChem Substance ID:
57651659
NACRES:
NA.77

assay

≥98.0% (HPLC)

form

powder

storage temp.

2-8°C

SMILES string

CC1CN(CCN1)S(=O)(=O)c2cccc3cnccc23

InChI

1S/C14H17N3O2S/c1-11-10-17(8-7-16-11)20(18,19)14-4-2-3-12-9-15-6-5-13(12)14/h2-6,9,11,16H,7-8,10H2,1H3

InChI key

QGSCXAWTTISKLF-UHFFFAOYSA-N

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Biochem/physiol Actions

Less potent inhibitor of protein kinaseC than H-7

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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C C Chua et al.
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The human pre-B acute lymphoblastic leukemia cell line REH6 was utilized for characterization of CD45 glycoprotein by monoclonal antibodies (mAb) recognizing four distinct CD45 antigen specificities, i.e. nonrestricted CD45, restricted CD45RA, CD45RB and CD45R0. Immunoprecipitation revealed two antigen specificities on
C D Balaban et al.
Brain research, 845(1), 97-101 (1999-10-26)
This study tests the hypothesis that activation of protein kinase C (PKC) is a critical step for early recovery from spontaneous nystagmus after unilateral ablation of the vestibular periphery. Halothane-NO(2)-O(2)-anesthetized Long-Evans rats received a 5-microl intracerebroventricular bolus of vehicle (distilled
B L Sailer et al.
Cytometry, 31(3), 208-216 (1998-03-27)
Fluorescence lifetime analysis was used in combination with conventional flow cytometric analysis to monitor changes in residual chromatin in apoptotic HL-60 cell populations following treatment with camptothecin, cycloheximide, genistein, H7, and gamma radiation. Data presented show that all of these
A Broberg et al.
Biochemical and biophysical research communications, 280(1), 328-333 (2001-02-13)
Integrin alpha1beta1, one of the cellular collagen receptors, can participate in the regulation of collagen accumulation by acting as a negative feedback regulator. The molecular mechanism behind this phenomenon has been unknown. We have plated cells inside three-dimensional collagen and
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