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46943

Sigma-Aldrich

Fluorescein dilaurate

suitable for fluorescence, ≥97.0% (HPCE)

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About This Item

Empirical Formula (Hill Notation):
C44H56O7
CAS Number:
7308-90-9
Molecular Weight:
696.91
Beilstein/REAXYS Number:
6034843
EC Number:
230-764-2
MDL number:
MFCD00038409
UNSPSC Code:
12352106
PubChem Substance ID:
57650888
NACRES:
NA.32

Quality Level

100

assay

≥97.0% (HPCE)

form

powder

solubility

ethanol: soluble

fluorescence

λex 490 nm; λem 514 nm in 0.1 M Tris pH 8.0 (esterase)

suitability

suitable for fluorescence

SMILES string

CCCCCCCCCCCC(=O)Oc1ccc2c(Oc3cc(OC(=O)CCCCCCCCCCC)ccc3C24OC(=O)c5ccccc45)c1

InChI

1S/C44H56O7/c1-3-5-7-9-11-13-15-17-19-25-41(45)48-33-27-29-37-39(31-33)50-40-32-34(49-42(46)26-20-18-16-14-12-10-8-6-4-2)28-30-38(40)44(37)36-24-22-21-23-35(36)43(47)51-44/h21-24,27-32H,3-20,25-26H2,1-2H3

InChI key

MYTRGBGGRICZGN-UHFFFAOYSA-N

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Application

Fluorescein dilaurate is suitable as fluorogenic substrate for esterases/lipases and used in the pancreolauryl test for chronic pancreatitis.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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F Seibold et al.
Journal of clinical gastroenterology, 22(3), 202-206 (1996-04-01)
Pancreatic autoantibodies (PABs) are found in 31% of patients with Crohn's disease (CD), but they do not correlate with the activity of intestinal disease or the incidence of acute pancreatitis. Exocrine pancreatic insufficiency has been observed in patients with CD.
I A Murray et al.
Postgraduate medical journal, 79(934), 471-473 (2003-09-05)
To audit the specificity and value of the pancreolauryl test (PLT) for the diagnosis of pancreatic insufficiency. A retrospective case note review of 47 patients who had a PLT during three consecutive years. A 650 bedded district general hospital. Patient
H Friess et al.
Pancreas, 13(2), 202-208 (1996-08-01)
The risk of developing postoperative complications following pancreatic resection depends mainly on how difficult it is to perform a proper pancreaticointestinal anastomosis. We have evaluated the serum pancreolauryl test, a rapid tubeless pancreatic function test, as a simple preoperative predictor
R S Chowdhury et al.
Alimentary pharmacology & therapeutics, 17(6), 733-750 (2003-03-19)
Pancreatic function tests are most commonly used to diagnose chronic pancreatitis. These tests include tests which document exocrine or endocrine gland insufficiency and tests which instead measure gradations of decreased secretory capacity. The tests in the former category generally become
L M Burrell et al.
Scandinavian journal of clinical and laboratory investigation, 51(8), 675-680 (1991-12-01)
We have employed an oral test of pancreatic digestive function using fluorescein dilaurate (a substrate for pancreatic cholesterol ester hydrolase), administered together with pancreatic enzyme supplements, in order to test the hypothesis that urinary excretion of fluorescein provides a simple
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