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38216

Sigma-Aldrich

N-[4-(5,6-Dimethoxy-N-phthalimidinyl)phenyl]maleimide

≥97.0% (HPLC)

Synonym(s):

DPM

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About This Item

Empirical Formula (Hill Notation):
C20H16N2O5
CAS Number:
143503-03-1
Molecular Weight:
364.35
UNSPSC Code:
12352200
PubChem Substance ID:
329755752

assay

≥97.0% (HPLC)

SMILES string

COc1cc2CN(C(=O)c2cc1OC)c3ccc(cc3)N4C(=O)C=CC4=O

InChI

1S/C20H16N2O5/c1-26-16-9-12-11-21(20(25)15(12)10-17(16)27-2)13-3-5-14(6-4-13)22-18(23)7-8-19(22)24/h3-10H,11H2,1-2H3

Inchi Key

ISCHQGBNSNVWCQ-UHFFFAOYSA-N

Application

N-[4-(5,6-Dimethoxy-N-phthalimidinyl)phenyl]maleimide (DPM) is used to fluorescence label proteins via their sulfhydryl groups. Nonfluorescent N-substituted maleimides react selectively with thiol compounds to form fluorescent derivatives. Fluorescent intensity of the dimethoxyphthalimidyl group is higher than that of the non substituted phthalimidyl group.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Drug transporters play a crucial role in pharmacokinetics. One subfamily of transporters with proven clinical relevance are the OATP1B transporters. Recently we identified a new member of the OATP1B family named OATP1B3-1B7 (LST-3TM12). This functional transporter is encoded by SLCO1B3
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