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282M-9

Sigma-Aldrich

HMB-45 (HMB-45) Mouse Monoclonal Antibody

clone HMB-45, unconjugated, Cell Marque™

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

HMB-45, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (282M-94)
vial of 0.5 mL concentrate (282M-95)
bottle of 1.0 mL predilute (282M-97)
vial of 1.0 mL concentrate (282M-96)
bottle of 7.0 mL predilute (282M-98)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG1κ

control

melanoma

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

General description

Anti-HMB45 is a useful melanoma immunohistochemical marker that reacts with antigenspresent on immature melanosomes. Anti-HMB45 is useful for identifying amelanoticmelanoma from other neoplastic lesions with similar morphology.

Quality


IVD
IVD
IVD
RUO

Linkage

HMB-45 Positive Control Slides, Product No. 282S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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An assessment of a melanoma-specific antibody (HMB-45) and other immunohistochemical markers of malignant in paraffin-embedded tissue.
AS-Y Leong, et al.
Surgical Pathology, 2, 137-145 (1989)
L Weiss et al.
The Journal of pathology, 150(3), 195-203 (1986-11-01)
The sequence of events in haematogenous metastasis from colonic carcinoma was analysed, using 1541 necropsy reports from 16 centres. The findings are consistent with the cascade hypothesis that metastases develop in discrete steps, first in the liver, next in the
Helene Nortvig Abrahamsen et al.
Cancer, 100(8), 1683-1691 (2004-04-10)
The optimal technique for sentinel lymph node (SN) assessment in patients with melanoma is controversial. Molecular analysis (reverse transcriptase-polymerase chain reaction) detects significantly greater numbers of SNs with suspected micrometastases (up to 71%) than does routine histopathology (approximately 20%). The
M R Wick et al.
Archives of pathology & laboratory medicine, 112(6), 616-620 (1988-06-01)
The efficacy of two new monoclonal antibodies with cell lineage-restricted reactivity (HMB-45 [melanocytes] and anti-synaptophysin [neuroepithelial cells]) was compared with that of "traditional" antibody panels in the delineation of malignant melanoma (MM) of the sinonasal region, nasopharyngeal carcinoma (NPC), and
L Vaggelli et al.
Tumori, 86(4), 346-348 (2000-10-04)
Elective lymph node dissection (ELND) for patients with malignant melanoma is still controversial. A possible alternative could be biopsy of the first tumor draining lymph node, the sentinel node (SN), which can be identified by means of radionuclide techniques. Our
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