17936

1α,25-Dihydroxyvitamin D₃

≥97.0% (HPLC)

• Synonym(s): 1α,25-Dihydroxycholecalciferol, Calcitriol
• Empirical Formula (Hill Notation): C₂₇H₄₄O₃
• CAS Number: 32222-06-3
• Molecular Weight: 416.64
• Beilstein/REAXYS Number: 7559394
• EC Number: 250-963-8
• MDL number: MFCD00867079
• UNSPSC Code: 12352205
• eCl@ss: 34058003
• PubChem Substance ID: 57647688
• NACRES: NA.79

Properties

• assay: ≥97.0% (HPLC)
• form: crystals
• color: white to off-white
• storage temp.: −70°C
• SMILES string: [H][C@@]1(CC[C@@]2([H])C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C)[C@H](C)CCCC(C)(C)O
• InChI: 1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
• InChI key: GMRQFYUYWCNGIN-NKMMMXOESA-N
• Gene Information: human ... VDR(7421)

Description

General description

1α,25-Dihydroxyvitamin D₃, also referred as calcitriol, is a calcitrophic hormone. It is the most biologically active metabolite of vitamin D produced in proximal tubular cells in the kidney.

Application

1α,25-Dihydroxyvitamin D₃ has been used to study its effect on transplantation success of human muscle precursor cells (hMPCs) in severe combined immunodeficient (SCID) mice in-vitro.

Biochem/physiol Actions

1α,25-Dihydroxyvitamin D₃ modulates energy metabolism by facilitating various metabolic processes, such as Ca²⁺ signaling and modulation of glucocorticoids, by affecting adipocyte apoptosis and by regulating the expression and production of multiple cytokines. In addition, it also modulates phosphorus homeostasis through actions in the intestine, kidney and bone. 1α,25-Dihydroxyvitamin D₃ exhibits antiproliferative effects and is used as a potent therapeutic for human prostate cancer.

Biologically active form of vitamin D₃ in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D₃ has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D₃ acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety Information

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H300 + H310 + H330,H372
• pcodes: P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P314
• Hazard Classifications: Acute Tox. 1 Oral - Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - STOT RE 1
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges