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Key Documents

02110

Sigma-Aldrich

S-(5′-Adenosyl)-L-methionine p-toluenesulfonate

≥85% (HPCE)

Synonym(s):

AdoMet

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About This Item

Empirical Formula (Hill Notation):
C22H30N6O8S2
CAS Number:
Molecular Weight:
570.64
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:

assay

≥85% (HPCE)

impurities

≤5% water

solubility

H2O: 0.1 g/mL, clear

storage temp.

−20°C

SMILES string

Cc1ccc(cc1)S([O-])(=O)=O.C[S+](CC[C@H](N)C(O)=O)C[C@H]2O[C@H]([C@H](O)[C@@H]2O)n3cnc4c(N)ncnc34

InChI

1S/C15H22N6O5S.C7H8O3S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;1-6-2-4-7(5-3-6)11(8,9)10/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25);2-5H,1H3,(H,8,9,10)/t7-,8+,10+,11+,14+,27?;/m0./s1

InChI key

VHPOFDUCFKOUHV-XKGORWRGSA-N

Biochem/physiol Actions

Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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