217565

Barium chloride dihydrate

ACS reagent, ≥99%

• Empirical Formula (Hill Notation): BaCl₂ · 2H₂O
• CAS Number: 10326-27-9
• Molecular Weight: 244.26
• EC Number: 233-788-1
• MDL number: MFCD00149154
• UNSPSC Code: 12352302
• PubChem Substance ID: 329752201
• NACRES: NB.24

Properties

• grade: ACS reagent
• assay: ≥99%
• form: powder, crystals or chunks
• impurities: ≤0.005% insolubles; ≤0.005% oxidizers
• loss: 14.0-16.0% loss on drying
• pH: 5.2-8.2 (25 °C, 5%)
• cation traces: Ca: ≤0.05%; Fe: ≤2 ppm; K: ≤0.0025%; Na: ≤0.005%; Sr: ≤0.1%; heavy metals: ≤5 ppm (by ICP-OES)
• SMILES string: O.O.Cl[Ba]Cl
• InChI: 1S/Ba.2ClH.2H2O/h;2*1H;2*1H2/q+2;;;;/p-2
• InChI key: PWHCIQQGOQTFAE-UHFFFAOYSA-L

Description

Application

Barium chloride dihydrate has been used:

• in patch-clamp electrophysiological studies to block subthreshold-activated potassium channels
• as an inward rectifier potassium (Kir) channel blocker to study the role of the channel by measuring the microglial membrane currents in response to voltage ramp stimuli after ATP injection
• to prepare the stock solution to make artificial cerebrospinal fluid (aCSF)

Biochem/physiol Actions

Barium chloride is a potassium ion channel blocker. It is considered toxic. Barium chloride prevents the D2-like receptor-mediated hyperpolarisation of spinal central pattern generator (CPG) neurons

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H319,H332
• pcodes: P261 - P264 - P271 - P301 + P310 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Eye Irrit. 2
• Storage Class: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable