PHR1799

Meloxicam

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Meloxicam, 4-Hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
• Empirical Formula (Hill Notation): C₁₄H₁₃N₃O₄S₂
• CAS Number: 71125-38-7
• Molecular Weight: 351.40
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• agency: traceable to BP 629; traceable to Ph. Eur. Y0001080; traceable to USP 1379401
• API family: meloxicam
• CofA: current certificate can be downloaded
• packaging: pkg of 500 mg
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• InChI: 1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,19H,1-2H3,(H,15,16)/b13-11+
• InChI key: DWMREKMVXIFPFM-ACCUITESSA-N

Description

General description

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Meloxicam is an oxicam derivative and belongs to the group of non-steroidal anti-inflammatory drugs (NSAID), used for its analgesic, anti-inflammatory, and antipyretic properties. It acts by inhibiting the activity of prostaglandin synthetase, thereby preventing the synthesis of prostaglandins and decreasing inflammation.

Application

This pharmaceutical secondary standard can also be used as follows:

• Development of three spectrophotometric methods to determine meloxicam in its pharmaceutical formulations
• Voltammetric determination of meloxicam in pharmaceutical formulations using a boron-doped diamond electrode (BDDE)
• High-performance liquid chromatography-based quantitative analysis of meloxicam in its different tablet formulations
• Development and validation of a reversed-phase HPLC method for the separation and estimation of meloxicam in its pharmaceutical dosage forms
• Quantification of meloxicam and piroxicam from plasma samples using a liquid chromatography method combined with UV detection

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7807 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

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Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable