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PHR1053

Supelco

Albuterol sulfate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Albuterol Sulfate

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About This Item

Empirical Formula (Hill Notation):
C26H44N2O10S
CAS Number:
Molecular Weight:
576.70
EC Number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

agency

traceable to BP 302
traceable to Ph. Eur. S0150000
traceable to USP 1012633

API family

albuterol, salbutamol

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Gene Information

human ... ADRB2(154)

General description

Albuterol sulfate is a β2 adrenergic agonist and a bronchodilating agent, which is used in the treatment of asthma.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

application

Albuterol sulfate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by ultra-performance liquid chromatographic method with ultraviolet detection (UPLC-UV).
Albuterol sulfate may be used as a reference standard in determining the concentration of albuterol sulfate present in inhalers using reversed-phase high performance liquid chromatography (RP-HPLC).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA7128 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

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pictograms

Health hazardExclamation mark

signalword

Warning

Hazard Classifications

Carc. 2 - Repr. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Supercritical and near-critical carbon dioxide assisted low-temperature bubble drying
Sievers.ER, et al.
Industrial & Engineering Chemistry Research, 39(12), 4831-4836 (2000)
Determination of albuterol sulfate and its related substances in albuterol sulfate inhalation solution, 0.5% by RP-HPLC
Erram.VS, et al.
Journal of Pharmaceutical and Biomedical Analysis, 40(4), 864-874 (2006)
Comparison of conventional HPLC with UPLC method for determination of albuterol sulfate and it?s impurities in pharmaceutical formulation.
Dalvi PN, et al.
Orient. J. Chem., 24(2), 537-544 (2008)
B Padhukasahasram et al.
The pharmacogenomics journal, 14(4), 365-371 (2014-01-15)
Inhaled short-acting beta-agonist (SABA) medication is commonly used in asthma patients to rapidly reverse airway obstruction and improve acute symptoms. We performed a genome-wide association study of SABA medication response using gene-based association tests. A linear mixed model approach was
Ashley Woodcock et al.
Chest, 144(4), 1222-1229 (2013-07-13)
The combination of fluticasone furoate (FF), a novel inhaled corticosteroid (ICS), and vilanterol (VI), a long-acting β2 agonist, is under development as a once-daily treatment of asthma and COPD. The aim of this study was to compare the efficacy of

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