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M1880000

Miconazole

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

(±)-1-[2-(2,4-Dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole

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About This Item

Empirical Formula (Hill Notation):
C18H14Cl4N2O
CAS Number:
22916-47-8
Molecular Weight:
416.13
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

miconazole

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

InChI

1S/C18H14Cl4N2O/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22/h1-8,11,18H,9-10H2

InChI key

BYBLEWFAAKGYCD-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Miconazole EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Related product

Product No.
Description
Pricing

PHR1163

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1443500

Miconazole nitrate, United States Pharmacopeia (USP) Reference Standard

M1900000

Miconazole nitrate, European Pharmacopoeia (EP) Reference Standard

Y0001620

2,4-Dichlorobenzyl alcohol, European Pharmacopoeia (EP) Reference Standard

1443409

Miconazole, United States Pharmacopeia (USP) Reference Standard

1443431

Miconazole Related Compound C, United States Pharmacopeia (USP) Reference Standard

1443464

Miconazole Related Compound F, United States Pharmacopeia (USP) Reference Standard

1443497

Miconazole Related Compound I, United States Pharmacopeia (USP) Reference Standard

BP253

Miconazole nitrate, British Pharmacopoeia (BP) Reference Standard

BP884

Miconazole impurity A, British Pharmacopoeia (BP) Reference Standard

PHR9002

1-[(2RS)-2-(Benzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazolium nitrate, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H413

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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D A Stevens et al.
The American journal of medicine, 60(2), 191-202 (1976-02-01)
Fourteen patients with chronic coccidioidomycosis, many of whom had complicating concurrent diseases and/or had failed to respond to amphotericin therapy, were treated with intravenous miconazole, a synthetic imidazole drug previously shown to be effective in experimental murine coccidioidomycosis. Up to
R C Heel et al.
Drugs, 19(1), 7-30 (1980-01-01)
Miconazole is an imidazole antifungal drug which has recently become available for systemic use. Its antifungal activity has been well studied and it is active in vitro against a wide range of fungi. Published and unpublished reports of the use
Pascale Quatresooz et al.
Expert opinion on pharmacotherapy, 9(11), 1927-1934 (2008-07-17)
Miconazole nitrate is a time-honored antifungal of the imidazole class. To revisit the various aspects of action of the drug in a dermatologic setting. Review of the current peer-reviewed publications. Miconazole essentially inhibits 14alpha-demethylase, an enzyme required for the biosynthesis
J Symoens
Proceedings of the Royal Society of Medicine, 70 Suppl 1, 4-8 (1977-01-01)
Intravenous treatment with miconazole brought about the recovery of 90% of patients with gastrointestinal or systemic candidosis. Miconazole given by the same route has also been found effective in the treatment of cryptococcosis, coccidioidomycosis, and paracoccidioidomycosis. Cryptococcal and coccidioidal meningitis
A Miki et al.
Journal of clinical pharmacy and therapeutics, 36(6), 642-650 (2010-12-15)
Miconazole is a strong inhibitor of CYP2C9, one of the main enzymes involved in the metabolism of warfarin. Concurrent use of the two drugs leads to potentially serious adverse effects. Although it is often assumed that use of the oral
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