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A5131

Sigma-Aldrich

L-Arginine monohydrochloride

≥98% (HPLC)

Synonym(s):

(S)-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride, (S)-(+)-Arginine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C6H14N4O2 · HCl
CAS Number:
Molecular Weight:
210.66
Beilstein/REAXYS Number:
3631658
EC Number:
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26

product name

L-Arginine monohydrochloride, reagent grade, ≥98% (HPLC), powder

grade

reagent grade

Quality Level

assay

≥98% (HPLC)

form

powder

color

white

mp

>235 °C

solubility

H2O: 50 mg/mL

application(s)

cell analysis

SMILES string

Cl[H].N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1

InChI key

KWTQSFXGGICVPE-WCCKRBBISA-N

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Application

L-Arginine monohydrochloride has been used to study the effects of amino acids in promoting food consumption in Drosophila melanogaster. It has also been used to develop a non-invasive chronic pancreatitis model of rat.

Biochem/physiol Actions

L-Arginine is a semi-essential amino acid. This dibasic amino acid acts as a precursor for creatinine and is a natural constituent of most of the dietary proteins.
Substrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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J. P. Felix D'Mello
Amino Acids in Human Nutrition and Health (2012)
Severe Chronic Pancreatitis due to Recurrent Acute Injury: Non-Invasive Chronic Pancreatitis Model of Rat
Surendra Sharma
Pancreas (2016)
An internal sensor detects dietary amino acids and promotes food consumption in Drosophila
Zhe Yang
Nature (2017)
Enyong Dai et al.
Nature communications, 11(1), 6339-6339 (2020-12-15)
Ferroptosis is a more recently recognized form of cell death that relies on iron-mediated oxidative damage. Here, we evaluate the impact of high-iron diets or depletion of Gpx4, an antioxidant enzyme reported as an important ferroptosis suppressor, in the pancreas
Jiao Liu et al.
Nature communications, 12(1), 647-647 (2021-01-30)
Ferroptosis is a type of iron-dependent regulated cell death, representing an emerging disease-modulatory mechanism. Transcription factors play multiple roles in ferroptosis, although the key regulator for ferroptosis in iron metabolism remains elusive. Using NanoString technology, we identify NUPR1, a stress-inducible

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