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93087

Supelco

4-(N,N-Dimethylsulfamoyl)-7-piperazino-benzofurazan

for fluorescence, ≥99.0%

Synonym(s):

N,N-Dimethyl-7-piperazino-4-benzofurazansulfonamide, DBD-PZ

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About This Item

Empirical Formula (Hill Notation):
C12H17N5O3S
CAS Number:
Molecular Weight:
311.36
MDL number:
UNSPSC Code:
12000000
PubChem Substance ID:
NACRES:
NA.22

grade

for fluorescence

Quality Level

assay

≥99.0% (HPLC)
≥99.0%

form

powder

technique(s)

HPLC: suitable

fluorescence

λex 408 nm; λem 585 nm in 0.1 M phosphate pH 7.0

SMILES string

CN(C)S(=O)(=O)c1ccc(N2CCNCC2)c3nonc13

InChI

1S/C12H17N5O3S/c1-16(2)21(18,19)10-4-3-9(11-12(10)15-20-14-11)17-7-5-13-6-8-17/h3-4,13H,5-8H2,1-2H3

InChI key

XFQLOSBBYVMBGT-UHFFFAOYSA-N

General description

DBD-PZ is a fluorogenic tagging reagent mostly used in HPLC for carboxylic acids.[1]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Reagent for the sensitive fluorometric detection of acids by HPLC (precolumn labeling)[2][3]

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pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Yuhki Tsukamoto et al.
Biomedical chromatography : BMC, 20(10), 1049-1055 (2006-03-01)
The combined use of a so-called internal standard and the isotope-labeled derivatization reagent for the quantification of analytes for liquid chromatography-mass spectrometry (LC/MS) was further studied. The sample solution (containing the analytes and an internal standard) was derivatized with the
Precolumn fluorescence tagging reagent for carboxylic acids in high-performance liquid chromatography: 4-substituted-7-aminoalkylamino-2, 1, 3-benzoxadiazoles.
Toyo'oka, Toshimasa, et al.
Journal of Chromatography A, 588.1-2, 61-71 (1991)
H Ichihara et al.
Analytical biochemistry, 269(2), 379-385 (1999-05-01)
A method is described for the quantitative determination of d- and L-lactate in 10 microl of rat serum, which includes fluorescence derivatization of D- and L-lactate with 4-(N, N-dimethylaminosulfonyl)-7-piperazino-2,1,3- benzoxadiazole (DBD-PZ) followed by O-acetylation. The derivatives are separated by HPLC
Y. Ueno et al.
Chemical & Pharmaceutical Bulletin, 47, 1375-1375 (1999)
H Hasegawa et al.
Journal of chromatography. B, Biomedical applications, 687(2), 419-425 (1996-12-13)
A simple and sensitive method for quantitation of HSR-609 (I) in human plasma and urine was developed using HPLC with the fluorescence labelling reagent 4-(N,N-dimethylaminosulfonyl)-7-N-piperazino-2,1,3-benzox adi azole (DBD-PZ). Compound I was extracted from human plasma and urine, and derivatized by

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