74177
Difenoconazol
certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
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About This Item
Empirical Formula (Hill Notation):
C19H17Cl2N3O3
CAS Number:
Molecular Weight:
406.26
Beilstein/REAXYS Number:
9073356
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24
Recommended Products
grade
certified reference material
TraceCERT®
Quality Level
100
300
product line
TraceCERT®
form
solid
shelf life
limited shelf life, expiry date on the label
manufacturer/tradename
Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
storage temp.
2-8°C
SMILES string
CC1COC(Cn2cncn2)(O1)c3ccc(Oc4ccc(Cl)cc4)cc3Cl
InChI
1S/C19H17Cl2N3O3/c1-13-9-25-19(27-13,10-24-12-22-11-23-24)17-7-6-16(8-18(17)21)26-15-4-2-14(20)3-5-15/h2-8,11-13H,9-10H2,1H3
InChI key
BQYJATMQXGBDHF-UHFFFAOYSA-N
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General description
This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ. Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate. Download your certificate at: http://www.sigma-aldrich.com.
Difenoconazole is a broad-spectrum systematic triazole fungicide that controls foliar, seed, and soil-borne diseases caused by ascomycetes, basidiomycetes, and deuteromycetes infecting tobacco, cereals, fruits, vegetables, ornamentals, and other crops. Difenoconazole inhibits fungal cytochrome P450 sterol 14α-demethylase (cyp51) activity and blocks ergosterol biosynthesis, thus hindering the chitin synthesis of the fungal cell, resulting in cell death. It has strong internal absorption and is characterized by high efficiency, broad-spectrum application, low toxicity, and low required dosage.
Difenoconazole has to be monitored in the Multiannual Control Programme for Pesticides Residues (MACP), run within the EU and EFTA in/on products of plant origin.
Difenoconazole is approved for use in European Union as per Regulation (EC) No 1107/2009. Maximum residue levels (MRLs) for Difenoconazole have been set according to Regulation (EU) No 2019/552 for products of animal origin from 0.005 to 0.2 mg/kg and plants from 0.05 to 20 mg/kg.
Difenoconazole is a broad-spectrum systematic triazole fungicide that controls foliar, seed, and soil-borne diseases caused by ascomycetes, basidiomycetes, and deuteromycetes infecting tobacco, cereals, fruits, vegetables, ornamentals, and other crops. Difenoconazole inhibits fungal cytochrome P450 sterol 14α-demethylase (cyp51) activity and blocks ergosterol biosynthesis, thus hindering the chitin synthesis of the fungal cell, resulting in cell death. It has strong internal absorption and is characterized by high efficiency, broad-spectrum application, low toxicity, and low required dosage.
Difenoconazole has to be monitored in the Multiannual Control Programme for Pesticides Residues (MACP), run within the EU and EFTA in/on products of plant origin.
Difenoconazole is approved for use in European Union as per Regulation (EC) No 1107/2009. Maximum residue levels (MRLs) for Difenoconazole have been set according to Regulation (EU) No 2019/552 for products of animal origin from 0.005 to 0.2 mg/kg and plants from 0.05 to 20 mg/kg.
Application
It is intended to be used as a certified reference material (CRM) for calibration in chromatography and other analytical techniques. Difenoconazole CRM may also find its use as described below:
- Study the developmental effects of difenoconazole and its mechanism on zebrafish embryos
- To develop a sample preparation and detection method for the determination of difenoconazole residue in banana fruits, pulp, and peels by GC-ECD
- Determination of difenoconazole residue in Chinese cabbage and soil using a solid phase extraction (SPE) cleanup and gas chromatography method
- Determination of difenoconazole residue in tomato paste during home canning using ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS)
- To develop an analytical method for the determination of abamectin and difenoconazole in stingless bee M. scutellaris by LC-MS/MS
Legal Information
TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Fernanda Scavassa Ribeiro do Prado et al.
Environmental pollution (Barking, Essex : 1987), 265(Pt B), 114313-114313 (2020-08-19)
Bees are considered as important providers of ecosystem services, acting via pollination process in crops and native plants, and contributing significantly to the maintenance of biodiversity. However, the decrease of bee's population has been observed worldwide and besides other factors
Qun Zheng et al.
Environmental science and pollution research international, 27(13), 15365-15374 (2020-02-23)
The dissipation and terminal residues of difenoconazole in whole bananas and pulp were investigated under field conditions. The residual levels of difenoconazole in various parts of bananas grown in Guangdong, Hainan and Yunnan were determined by a GC-ECD detection method
Xiyan Mu et al.
Environmental pollution (Barking, Essex : 1987), 212, 18-26 (2016-02-04)
Difenoconazole is a widely used triazole fungicide and has been reported to have negative impacts on zebrafish embryos. To investigate the mechanism of its developmental toxicity, zebrafish embryos were exposed to 0.5 and 2.0 mg/L difenoconazole for 96 h. The morphological and
Cong Guo et al.
Bulletin of environmental contamination and toxicology, 85(4), 427-431 (2010-09-25)
Difenoconazole was a triazole fungicide with proven bio-efficacy which leads to morphological and functional changes in the fungal cell membrane. In this work, field trials were conducted in three apple orchards. Sampling methods were improved in both the terminal residual
Cong Guo et al.
Bulletin of environmental contamination and toxicology, 85(4), 427-431 (2010-09-25)
Difenoconazole was a triazole fungicide with proven bio-efficacy which leads to morphological and functional changes in the fungal cell membrane. In this work, field trials were conducted in three apple orchards. Sampling methods were improved in both the terminal residual
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